Central cardiovascular and thermal effects of prostaglandin F2 alpha in rats

Prostaglandins
H KarppanenA Eskeli-Kaivosoja

Abstract

Administration of PGF2 ALPHA (0.2--6.4 micrograms) into the lateral cerebral ventricle (i.c.v.) induced dose-dependent increases in blood pressure, heart rate and body temperature in urethane-anaesthetised rats, but had no effect on these parameters when the same dose range was administered intravenously. Peripheral pretreatment with sodium meclofenamate (50 mg/kg s.c.) shifted all the dose-response curves for PGF2 alpha (i.c.v.) to the left, but indomethacin (50 mg/kg s.c.) did not significantly affect those changes. Central pretreatment with sodium meclofenamate or indomethacin (1.25 mg per rat i.c.v.) failed to modify significantly the effects of centrally administered PGF2 alpha. The results support previous suggestions that PGF2 alpha may participate in the central control of the cardiovascular and thermoregulatory systems, and also suggest that there may be differences in the sites and/or modes of action between sodium meclofenamate and indomethacin.

Citations

Jan 28, 1983·European Journal of Pharmacology·E K Chiu, J S Richardson
Sep 13, 1989·European Journal of Pharmacology·S Ekholm
Jun 1, 1982·Prostaglandins·W E HoffmanD J Miletich
Apr 1, 1982·Prostaglandins, Leukotrienes, and Medicine·A L Sirén
Jan 1, 1983·General Pharmacology·E K Chiu, J S Richardson
Nov 1, 1982·Acta Physiologica Scandinavica·A L Sirén

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