Central cardiovascular effects of nylidrin (buphenine)

European Journal of Pharmacology
B Fichtl, W Felix

Abstract

The injection of small doses of nylidrin into the vertebral artery lowered blood pressure in chloralose-anesthetized cats. Cerebroventricular perfusion of nylidrin also decreased blood pressure and inhibited or modified cardiovascular reflexes. There was inhibition of the reflex bradycardia evoked by i.v. noradrenaline or angiotensin. Likewise the pressure increase due to bilateral carotid occlusion was diminished. The blood pressure decrease elicited by stimulation of the central stump of a cut vagus nerve was inhibited or reversed. The pattern of central cardiovascular effects of nylidrin seemed not compatible with its well known beta-sympathomimetic properties. Indirect evidence points to an interasction with central alpha-receptors.

References

Jan 1, 1976·Annual Review of Pharmacology and Toxicology·A ScriabineC S Sweet
May 1, 1978·British Journal of Pharmacology·K P BhargavaK K Tangri
May 1, 1977·European Journal of Pharmacology·R R Vollmer, J P Buckley
Aug 1, 1971·The International Journal of Neuroscience·J H HubbardW H Marshall
Jul 1, 1974·Clinical and Experimental Pharmacology & Physiology·M D Day, A G Roach
May 1, 1972·Stroke; a Journal of Cerebral Circulation·W K Mitchell, W A Himwich
Nov 1, 1968·European Journal of Pharmacology·F Bergmann, A Ramu
Feb 17, 1958·The Journal of Physiology·R L HOLMESJ H WOLSTENCROFT
Aug 1, 1965·British Journal of Pharmacology and Chemotherapy·A S Burgen, L L Iversen

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Citations

Jan 16, 1998·European Journal of Pharmacology·E R WhittemoreR M Woodward

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