Central catecholamine depletion impairs in vivo immunity but not in vitro lymphocyte activation

Journal of Neuroimmunology
R J Cross, T L Roszman

Abstract

We have previously shown that depletion of central nervous system (CNS) catecholamines by injecting the neurotoxin 6-hydroxydopamine (6-OHDA) into the cisterna magna of C57B1/6 mice markedly impairs the humoral immune response to sheep red blood cells. This work extends these observations by showing that 6-OHDA treatment also inhibits the humoral antibody response to the T-cell-dependent antigen trinitrophenyl-keyhole limpet hemocyanin, but does not affect the response to the T-independent antigen trinitrophenyl-lipopolysaccharide. This treatment also impairs humoral responsiveness at peripheral lymphoid sites in addition to inhibiting natural killer cell activity. However, 6-OHDA treatment in vivo does not affect in vitro mixed lymphocyte responsiveness, mitogen-induced lymphocyte activation or antigen presentation by macrophages.

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Citations

Aug 1, 1996·Progress in Neuro-psychopharmacology & Biological Psychiatry·F LechinM Benaim
Oct 29, 1993·Annals of the New York Academy of Sciences·M Irwin
Nov 6, 2002·Journal of Neuroimmunology·Nikolay M FilipovDavid A Lawrence
May 23, 2008·Journal of Neuroimmunology·Amanda TempletonDaniel J J Carr
Jul 31, 2003·Journal of Neurochemistry·Gustavo Pacheco-LópezManfred Schedlowski
Jun 28, 2005·Journal of Neuroimmunology·S L KennedyM Fleshner
Jun 21, 2011·Neurobiology of Disease·Marie-Therese ArmenteroFabio Blandini

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