Central catecholamine depletion impairs in vivo immunity but not in vitro lymphocyte activation

Journal of Neuroimmunology
R J Cross, T L Roszman


We have previously shown that depletion of central nervous system (CNS) catecholamines by injecting the neurotoxin 6-hydroxydopamine (6-OHDA) into the cisterna magna of C57B1/6 mice markedly impairs the humoral immune response to sheep red blood cells. This work extends these observations by showing that 6-OHDA treatment also inhibits the humoral antibody response to the T-cell-dependent antigen trinitrophenyl-keyhole limpet hemocyanin, but does not affect the response to the T-independent antigen trinitrophenyl-lipopolysaccharide. This treatment also impairs humoral responsiveness at peripheral lymphoid sites in addition to inhibiting natural killer cell activity. However, 6-OHDA treatment in vivo does not affect in vitro mixed lymphocyte responsiveness, mitogen-induced lymphocyte activation or antigen presentation by macrophages.


Jun 1, 1975·The Journal of Experimental Medicine·M D Jacobs, D C Morrison
May 1, 1977·European Journal of Immunology·H BesedovskyH Haas
Nov 1, 1975·Proceedings of the Society for Experimental Biology and Medicine·H BesedovskyJ Müller
Jan 1, 1987·Journal of Neuroscience Research·R J CrossT L Roszman
Dec 1, 1972·Cellular Immunology·R Bösing-Schneider, B Kindred
Nov 1, 1969·Proceedings of the Society for Experimental Biology and Medicine·M B Rittenberg, K L Pratt
Dec 1, 1981·Acta Endocrinologica·I BercziE Horvath
Jul 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·H M JohnsonJ E Blalock
Jul 1, 1982·Annals of Neurology·W H BrooksW R Markesbery
Aug 5, 1983·Science·H BesedovskyC Honegger

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