PMID: 2790501Jun 1, 1989

Central catecholaminergic responses in hypoxic moderation of spontaneous hypertension

Brain Research Bulletin
W N Henley, L L Bellush

Abstract

Exposure to hypobaric hypoxia (H; simulated altitude = 3658 m) was initiated in 5-week-old, male spontaneously hypertensive (SHR) and Wistar-Kyoto (WKy) normotensive rats while normoxic controls (N) for both groups were maintained under laboratory conditions. Significant attenuation of systolic arterial blood pressure was evident in SHR-H relative to SHR-N (125 +/- 6 vs. 145 +/- 5, mmHg; p less than 0.05) while blood pressure in the normotensive, Wistar-Kyoto rat was not affected by 20 days of exposure to hypoxia (WKy-H, 116 +/- 2 vs. WKy-N, 117 +/- 5, mmHg). Increased contents of norepinephrine and dopamine in brain stem, striatum, hypothalamus, and frontal cortex in SHR versus WKy indicated a possible involvement of central catecholaminergic mechanisms with spontaneous hypertension. Hypoxia significantly decreased neuronal contents of both neurotransmitters, typically on both days studied (days 4 and 21 of altitude treatment). In striatum and hypothalamus, dihydroxyphenylacetic acid to dopamine ratios indicated that dopamine turnover was decreased with hypoxia. Hypoxia elicits catecholaminergic responses consistent with profiles found following ICV administration of 6-hydroxydopamine, a sympatholytic agent that also prevents ...Continue Reading

References

Jan 1, 1985·Journal of Cardiovascular Pharmacology·R A GillisJ A Quest
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Citations

Feb 1, 1990·Physiology & Behavior·L L Bellush, W N Henley
Oct 1, 1996·Physiology & Behavior·R LiE C Fletcher
Mar 1, 1995·Pharmacology, Biochemistry, and Behavior·V P GeorgievM Opitz
Jan 1, 1992·Clinical and Experimental Hypertension. Part A, Theory and Practice·W N HenleyM A Notestine
Apr 15, 2008·Experimental Biology and Medicine·Tatiana V SerebrovskayaRobert T Mallet

Related Concepts

Metazoa
Anoxemia
Diastolic Blood Pressure
Brain
Intropin
Hypertensive Disease
Norepinephrine, (+, -)-Isomer
Rats, Inbred SHR
August Rats
Rats, Laboratory

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