PMID: 8941520Nov 1, 1996Paper

Central chemoreception in the region of the ventral respiratory group in the rat

Journal of Applied Physiology
E E Nattie, Aihua Li

Abstract

We injected acetazolamide (AZ; 5 x 10(-6) M, 1 nl) into the region of the ventral respiratory group (VRG) of anesthetized paralyzed ventilated rats. Control injections (mock cerebrospinal fluid, n = 6, or the inactive AZ analogue 2-acetylamino-1,3, 4-thiadiazole-5-sulfon-t-butylamide, n = 6) did not increase the integrated phrenic neurogram [phrenic nerve amplitude (PNA)]. The AZ injections produced a focal region of tissue acidosis with a radius < 300-400 microns and are used as a probe for sites of central chemosensitivity. Injection location is determined by anatomic analysis. Of 22 VRG injections of AZ, 14 increased the amplitude of the PNA over 15-90 min; 8 had no effect. In 17 cases, we measured medullary tissue pH at the injection center and/or at a distant site and reaffirmed the size of the acidotic region produced by such small AZ injections. Of injections with pH electrodes within 300-400 microns of the injection center, all responders showed an acid pH; three nonresponders showed an acid pH, and one an alkaline pH. In a subgroup of five rats, at VRG sites with known respiratory effects identified by prior glutamate injection (10 nl, 100 mM), all subsequent AZ injections produced a PNA response. Simultaneous measurem...Continue Reading

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Citations

Jul 23, 2002·Journal of Applied Physiology·Yasumasa OkadaFrederic L Eldridge
Feb 7, 2003·Journal of Applied Physiology·Barbara E TaylorJ C Leiter
Feb 25, 2003·Annual Review of Neuroscience·Jack L FeldmanEugene E Nattie
Feb 1, 1997·Journal of Applied Physiology·M R AkileshE E Nattie
Nov 18, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·S C HemplemanR S Begay
Nov 5, 2004·American Journal of Physiology. Cell Physiology·Robert W PutnamNicola A Ritucci
Nov 15, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Barbara E TaylorMatthew J Gdovin
Dec 2, 2008·Experimental Physiology·K Michael Spyer
Jan 11, 2019·American Journal of Physiology. Lung Cellular and Molecular Physiology·Jianguo ZhuangFadi Xu
Jun 16, 2000·The Journal of Physiology·D Ballantyne, P Scheid
Nov 6, 1998·Journal of Applied Physiology·J S ErlichmanE E Nattie
Jun 13, 2006·High Altitude Medicine & Biology·Fabiola León-Velarde, Jean-Paul Richalet
Nov 6, 2012·Annual Review of Physiology·Jack L FeldmanPaul A Gray
Jun 19, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Donatella MutoloTito Pantaleo
Jun 14, 2000·Journal of Applied Physiology·I C SolomonM H O'Neal
Aug 21, 2001·Journal of Child Neurology·H PhilippiB Reitter
Apr 30, 1999·Physiological Reviews·G Hilaire, B Duron
Mar 15, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·C S TorgersonJ E Remmers
Apr 1, 2003·The Journal of Physiology·J L Ribas-SalgueiroJ Ribas
Aug 12, 2006·The Journal of Physiology·Thiago S MoreiraPatrice G Guyenet
Jul 19, 2008·Journal of Applied Physiology·Shereé M JohnsonGeorge B Richerson
Mar 15, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·C S TorgersonJ E Remmers

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