Central cholinergic control of cerebral blood flow in the baboon. Effect of cholinesterase inhibition with neostigmine on autoregulation and CO2 responsiveness

Journal of Neurosurgery
M AoyagiA N Chee

Abstract

Cerebral autoregulation and vastomotor responsiveness to carbon dioxide (CO2) were measured quantitatively by the use of the autoregulation index and chemical index, respectively, in normal baboons before and after intravertebral and intracarotid infusion of the anticholinesterase agent, neostigmine methylsufate (Prostigmin). Continuous measurements were made of cerebral blood flow (measured as bilateral internal jugular venous outflow), arterial and cerebral venous pO2 and pCO2, cerebral arteriovenous oxygen differences, and endotracheal CO2. The effect of intravertebral infusion of neostigmine (12.5 mug/kg body weight) was compared to intravertebral infusion of neostigmine (25 mug/kg body weight) for assessment of any specific action of the drug on a hypothetical cholinergic vasomotor center, presumed to be located in the territory of the vertebrobasilar supply. No significant or persistent changes in cerebral blood flow (CBF) and cerebral metabolic rate for oxygen (CMRO2) followed either intravertebral or intracarotid infusion of neostigmine. Cerebral vascular resistance (CVR) and cerebral perfusion pressure (CPP), however, decreased significantly after intravertebral infusion. Cerebral autoregulatory vasoconstriction during...Continue Reading

References

Mar 1, 1975·Stroke; a Journal of Cerebral Circulation·E O OttN T Mathew
Dec 1, 1975·Journal of Neurosurgery·Y KawamuraE O Ott
Feb 1, 1969·Electroencephalography and Clinical Neurophysiology·J S MeyerA Kondo
Sep 1, 1973·Stroke; a Journal of Cerebral Circulation·S Q ShaferR W Richter
Jan 1, 1971·European Neurology·V D DeshmukhW B Jennett
May 1, 1969·The Journal of Physiology·K Lederis, A Livingston
May 12, 1972·Brain Research·M Glickstein
Nov 1, 1973·Stroke; a Journal of Cerebral Circulation·A A RovereA Giardini
Jun 6, 1972·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·S A KulasooriyaP Fay
Jun 1, 1974·Circulation Research·N A Lassen
Jan 1, 1972·Zeitschrift für Zellforschung und mikroskopische Anatomie·L EdvinssonB Sporrong
Mar 1, 1973·Stroke; a Journal of Cerebral Circulation·J S MeyerA Koto
Mar 1, 1973·Stroke; a Journal of Cerebral Circulation·J S MeyerA D Ericsson
Mar 1, 1973·Stroke; a Journal of Cerebral Circulation·V D Salanga, A G Waltz
Mar 1, 1973·Stroke; a Journal of Cerebral Circulation·O U ScreminA Giardini
May 1, 1973·Stroke; a Journal of Cerebral Circulation·E F SteinmetzM J Aguilar
Jul 1, 1968·The American Journal of Physiology·T W Langfitt, N F Kassell
Jul 1, 1969·Circulation Research·I M JamesM J Purves
Mar 1, 1971·Neurology·J S MeyerA Kondo
Jan 1, 1972·Brain : a Journal of Neurology·P AshbyJ W Lance
Jun 1, 1972·European Journal of Clinical Investigation·H D Söling, K O Unger
Jan 1, 1970·Pflügers Archiv : European journal of physiology·G I Mchedlishvili, L S Nikolaishvili
Jan 15, 1970·Life Sciences. Pt. 1: Physiology and Pharmacology·H E Brezenoff, T S Wirecki
Jul 1, 1971·The American Journal of Physiology·H M ShapiroC A Wiederhielm
Dec 1, 1968·Circulation·I H Page
May 1, 1966·Circulation·J A MazzarellaE Green
Oct 1, 1967·Archives of Neurology·M N ShalitP Scheinberg
Oct 1, 1967·Archives of Neurology·M N ShalitP Scheinberg
Oct 1, 1967·Circulation Research·C E RapelaA B Denison
Jan 1, 1957·Journal of Applied Physiology·A C GUYTONC FARISH
Feb 1, 1958·Electroencephalography and Clinical Neurophysiology·P B BRADLEY, B J KEY
Mar 23, 1963·Nature·A GILMANJ M RITCHIE
Jan 1, 1963·The Journal of Physiology·S M HILTON, A W ZBROZYNA
Jan 1, 1964·The American Journal of Physiology·M REIVICH
Jun 1, 1960·Journal of Ultrastructure Research·D C PEASE, S MOLINARI

❮ Previous
Next ❯

Citations

Mar 1, 1991·Journal of Neuroscience Research·O U ScreminK S Blisard
Jan 1, 1996·Life Sciences·O U Scremin, D J Jenden
Oct 1, 1976·Journal of Neurosurgery·M MatsudaY Tagashira
Mar 1, 1978·Journal of Neurosurgery·M MatsudaH Handa
Jul 1, 1993·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·O U ScreminB P Imbimbo
May 1, 1990·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·U Dirnagl, W Pulsinelli
Mar 1, 1978·Stroke; a Journal of Cerebral Circulation·O U ScreminR R Sonnenschein
Sep 1, 1977·Circulation Research·L G D'Alecy, C J Rose
Mar 1, 1987·Stroke; a Journal of Cerebral Circulation·D ReicherE H Rubinstein
Sep 1, 1986·Stroke; a Journal of Cerebral Circulation·O U Scremin, A M Scremin
Apr 1, 1978·Circulation Research·T J LeeJ A Bevan

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.