Central cholinergic system mediates working memory deficit induced by anesthesia/surgery in adult mice

Brain and Behavior
Xiao ZhangDiansan Su

Abstract

Postoperative cognitive dysfunction (POCD) is consistently associated with increased morbidity and mortality, which has become a major concern of patients and caregivers. Although POCD occurs mainly in aged patients, it happens at any age. Previous studies demonstrated that anesthesia/surgery had no effects on reference memory of adult mice. However, whether it impairs working memory remains unclear. Working memory deficit would result in many deficits of executive function. We hypothesized that anesthesia/surgery impaired the working memory of adult mice and the central cholinergic system was involved. Tibial fracture internal fixation under the anesthesia of isoflurane was performed in two-month-old C57BL/6 mice. Two days later, the spatial reference memory and working memory were measured by a Morris Water Maze (MWM). Donepezil, an inhibitor of acetylcholinesterase (AChE), was administered in another cohort mice for 4 weeks. Then, the working memory was measured by MWM 2 days after anesthesia/surgery. Western blot was used to detect the protein levels of acetylcholine transferase (ChAT), AChE, vesicular acetylcholine transporter (VAChT), and choline transporter (ChT) in the prefrontal cortex (PFC). We found that anesthesia/s...Continue Reading

References

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Dec 14, 2016·Mediators of Inflammation·Yanhua ZhaoDiansan Su

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Citations

Jun 11, 2020·Expert Opinion on Drug Metabolism & Toxicology·Ramón Cacabelos
Jul 28, 2020·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Maria HeinrichClaudia D Spies
Mar 28, 2020·Mediators of Inflammation·Xiaoxin ZhouDiansan Su

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Methods Mentioned

BETA
protein assays
electrophoresis

Software Mentioned

Statistical Package for the Social Sciences ( SPSS )
MWM

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