Central control of visceral pain and urinary tract function.

Autonomic Neuroscience : Basic & Clinical
T A Lovick

Abstract

Afferent input from Aδ and C-fibres innervating the urinary bladder are processed differently by the brain, and have different roles in signaling bladder sensation. Aδ fibres that signal bladder filling activate a spino-bulbo-spinal loop, which relays in the midbrain periaqueductal grey (PAG) and pontine micturition centre (PMC). The excitability of this circuitry is regulated by tonic GABAergic inhibitory processes. In humans and socialised animals micturition is normally under volitional control and influenced by a host of psychosocial factors. Higher nervous decision-making in a social context to 'go now' or 'do not go' probably resides in frontal cortical areas, which act as a central control switch for micturition. Exposure to psychosocial stress can have profoundly disruptive influence on the process and lead to maladaptive changes in the bladder. During sleeping the voiding reflex threshold appears to be reset to a higher level to promote urinary continence. Under physiological conditions C-fibre bladder afferents are normally silent but are activated in inflammatory bladder states and by intense distending pressure. Following prolonged stimulation visceral nociceptors sensitise, leading to a lowered threshold and height...Continue Reading

References

Oct 1, 1992·Trends in Neurosciences·F Cervero, W Jänig
Jan 14, 1998·Urology·W C de Groat
Nov 24, 1999·Trends in Cognitive Sciences·R Adolphs
Jan 24, 2002·American Journal of Physiology. Gastrointestinal and Liver Physiology·S V CoutinhoE A Mayer
Aug 13, 2002·Autonomic Neuroscience : Basic & Clinical·Ryuji SakakibaraTakamichi Hattori
Jun 17, 2003·Neurourology and Urodynamics·Kimio SugayaShigemi Mori
Jun 28, 1955·The Journal of Physiology·A IGGO
Jul 20, 2004·Journal of Neurology, Neurosurgery, and Psychiatry·H YaguchiK Tashiro
Nov 1, 2005·Autonomic Neuroscience : Basic & Clinical·Adam P KlausnerWilliam D Steers
Nov 24, 2005·The Journal of Comparative Neurology·Rutger KuipersGert Holstege
Jan 28, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Darcie A KiddooDimitri E Grigoriadis
Oct 6, 2007·The Journal of Physiology·Vladimir P ZagorodnyukSarah J Gregory
Apr 17, 2008·PloS One·Elizabeth A ClementClayton T Dickson
May 21, 2008·Nature Reviews. Neuroscience·Clare J FowlerWilliam C de Groat
Jul 23, 2008·Proceedings of the National Academy of Sciences of the United States of America·Elizabeth RickenbacherRita J Valentino
Apr 7, 2009·European Journal of Pain : EJP·Tian-Ying HuangMenachem Hanani
Jul 10, 2009·American Journal of Physiology. Renal Physiology·Andy ChangStephen Zderic
Aug 29, 2009·The Journal of Pain : Official Journal of the American Pain Society·Alban Latremoliere, Clifford J Woolf
Sep 11, 2009·Journal of Neurophysiology·Changfeng TaiWilliam C de Groat
Dec 22, 2009·Neurourology and Urodynamics·M J DrakeL Birder
Dec 22, 2009·Neurourology and Urodynamics·Gert Holstege
Mar 20, 2010·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·S Bradesi
May 18, 2010·Urological Research·Katja Venborg PedersenPalle Jørn Sloth Osther
Jul 28, 2010·Human Brain Mapping·Ulrich MehnertSpyros Kollias
Dec 8, 2010·Nature Reviews. Urology·Rita J ValentinoStephen A Zderic
Nov 1, 2011·Neurourology and Urodynamics·Phillip P SmithGeorge A Kuchel
Jan 24, 2012·The Journal of Urology·Saori NishijimaHideyuki Yamamoto
Apr 19, 2012·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·M M WoutersG Boeckxstaens
Oct 5, 2012·Acta Physiologica·W C de Groat, C Wickens
Oct 23, 2012·Psychoneuroendocrinology·L TranB Greenwood Van-Meerveld
Nov 21, 2012·Acta Physiologica·D J Griffiths, C J Fowler
Dec 18, 2012·BJOG : an International Journal of Obstetrics and Gynaecology·J I Gillespie
Feb 23, 2013·The Journal of Urology·Hiromitsu NegoroOsamu Ogawa
Apr 5, 2013·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Susan K WoodRita J Valentino
Aug 24, 2013·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·R M van den WijngaardG E Boeckxstaens
Apr 20, 2014·Indian Journal of Urology : IJU : Journal of the Urological Society of India·Martin HennenbergChristian Gratzke

❮ Previous
Next ❯

Citations

Jun 6, 2018·Frontiers in Systems Neuroscience·Dale E Bjorling, Zun-Yi Wang
Jan 9, 2019·Frontiers in Neuroscience·Luke GrundyStuart M Brierley
May 31, 2019·International Journal of Urology : Official Journal of the Japanese Urological Association·Lori A Birder

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Signaling & Cancer Epigenetics (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. This feed covers the latest research on signaling and epigenetics in cell growth and cancer.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Bladder Carcinoma In Situ

Bladder Carcinoma In Situ is a superficial bladder cancer that occurs on the surface layer of the bladder. Discover the latest research on this precancerous condition in this feed.

Related Papers

Plastic and Reconstructive Surgery
Adeline Fong, Stephan A Schug
Proceedings of the Finnish Dental Society. Suomen Hammaslääkäriseuran Toimituksia
T A Lovick
© 2022 Meta ULC. All rights reserved