Central CYP1B1 (Cytochrome P450 1B1)-Estradiol Metabolite 2-Methoxyestradiol Protects From Hypertension and Neuroinflammation in Female Mice.

Hypertension
Purnima SinghKafait U Malik

Abstract

Previously, we showed that peripheral administration of 2-ME (2-methoxyestradiol), a CYP1B1 (cytochrome P450 1B1)-catechol-O-methyltransferase (COMT) generated metabolite of E2 (17β-Estradiol), protects against angiotensin II-induced hypertension in female mice. The demonstration that central E2 inhibits angiotensin II-induced hypertension, together with the expression of CYP1B1 in the brain, led us to hypothesize that E2-CYP1B1 generated metabolite 2-ME in the brain mediates its protective action against angiotensin II-induced hypertension in female mice. To test this hypothesis, we examined the effect of intracerebroventricularly (ICV) administered E2 in ovariectomized (OVX)-wild-type (Cyp1b1+/+) and OVX-Cyp1b1-/- mice on the action of systemic angiotensin II. ICV-E2 attenuated the angiotensin II-induced increase in mean arterial blood pressure, impairment of baroreflex sensitivity, and sympathetic activity in OVX-Cyp1b1+/+ but not in ICV-injected short interfering (si)RNA-COMT or OVX-Cyp1b1-/- mice. ICV-2-ME attenuated the angiotensin II-induced increase in blood pressure in OVX-Cyp1b1-/- mice; this effect was inhibited by ICV-siRNA estrogen receptor-α (ERα) and G protein-coupled estrogen receptor 1 (GPER1). ICV-E2 in OVX-Cy...Continue Reading

References

Sep 1, 1994·Frontiers in Neuroendocrinology·C SumnersP Posner
May 1, 1993·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·A K Johnson, P M Gross
Dec 16, 1998·Molecular Pathology : MP·C R RiederA C Williams
Jan 13, 2001·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·L MuskhelishviliF F Kadlubar
Sep 25, 2001·Journal of Applied Physiology·R K Dubey, E K Jackson
Mar 4, 2003·Journal of Neurophysiology·Kevin J Latchford, Alastair V Ferguson
Jan 1, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Baojian XueMeredith Hay
May 18, 2005·Brain Research. Molecular Brain Research·Justyna PawlakCordian Beyer
Dec 5, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Baojian XueMeredith Hay
Sep 8, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Baojian XueAlan Kim Johnson
Dec 17, 2009·Hypertension·Robin L Davisson, Matthew C Zimmerman
Jun 16, 2010·Hypertension·Peng ShiMohan K Raizada
Mar 16, 2012·Biology of Sex Differences·Kathryn Sandberg, Hong Ji
Nov 23, 2013·European Journal of Pharmacology·Sivaramakrishna KogantiThomas Thekkumkara
Mar 4, 2014·Advances in Physiology Education·Daniel W Trott, David G Harrison
Jan 2, 2015·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Baojian XueAlan Kim Johnson
Jan 7, 2016·American Journal of Physiology. Endocrinology and Metabolism·Sara A SchaufelbergerRaghvendra K Dubey
May 4, 2017·The Journal of Steroid Biochemistry and Molecular Biology·Maria M Hadjimarkou, Nandini Vasudevan
Oct 10, 2018·American Journal of Hypertension·Lindsey A Ramirez, Jennifer C Sullivan
Oct 1, 2019·Hypertension·Snigdha MukerjeeEric Lazartigues

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.