Central defect type partial ACL injury model on goat knees: the effect of infrapatellar fat pad excision

Journal of Orthopaedic Surgery and Research
Bekir KarakilicElcil Kaya Bicer

Abstract

The mid-substance central defect injury has been used to investigate the primary healing capacity of the anterior cruciate ligament (ACL) in a goat model. The sagittal plane stability on this model has not been confirmed, and possible effects of fat pad excision on healing have not been evaluated. We hypothesize that excising the fat pad tissue results in poorer ligament healing as assessed histologically and decreased tensile strength of the healing ligament. We further hypothesize that the creation of a central defect does not affect sagittal plane knee stability. A mid-substance central defect was created with a 4-mm arthroscopic punch in the ACLs of right knees of all the subjects through a medial mini-arthrotomy. Goats were assigned to groups based on whether the fat pad was preserved (group 1, n = 5) or excised completely (group 2, n = 5). The left knees served as controls in each goat. Histopathology of the defect area along with measurement of type I collagen in one goat from each group were performed at 10th week postoperatively. The remaining knees were evaluated biomechanically at the 12th week, by measuring anterior tibial translation (ATT) of the knee joints at 90° of flexion and testing tensile properties (ultimat...Continue Reading

References

May 1, 1991·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·M E WiigK E Arfors
Jan 1, 1991·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·D L PowersM J Drews
Jul 1, 1987·The American Journal of Sports Medicine·D W JacksonT M Simon
Jul 1, 1995·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·G Y NgD Lampard
May 1, 1997·Journal of Biomechanics·S L WooT Yamaji
Jan 8, 1998·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·W R LundbergB C Poff
Sep 20, 2001·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·B C FlemingB D Beynnon
Mar 29, 2002·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·J F CummingsF R Noyes
Oct 18, 2002·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Robert C BrayPaul T Salo
Oct 18, 2002·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·J F Cummings, E S Grood
Jun 12, 2003·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Steven D AbramowitchSavio L-Y Woo
Oct 14, 2003·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Robert C BrayPaul T Salo
Feb 16, 2006·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·K P SpindlerJ M Davidson
Mar 24, 2006·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Martha M MurrayDavid Zurakowski
Apr 7, 2007·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Martha M MurrayLillian B Nanney
Nov 15, 2008·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Kurt P SpindlerBraden C Fleming
Dec 10, 2008·Clinics in Sports Medicine·Martha M Murray
Apr 10, 2009·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·T TischerFreddie H Fu
Mar 24, 2010·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Matthew B FisherSavio L-Y Woo
Feb 5, 2011·Sports Medicine and Arthroscopy Review·Patrick Vavken, Martha M Murray
Aug 20, 2011·The Knee·Benedikt L ProffenMartha M Murray
May 6, 2015·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Chao-Ying WangGuo-Shu Huang
Jun 21, 2015·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Nathan M SolbakDavid A Hart

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Software Mentioned

SPSSv18

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.