PMID: 489843Sep 1, 1979Paper

Central denervation hypersensitivity in the auditory system of the cat

The Journal of the Acoustical Society of America
G M Gerken

Abstract

Data are reported for seven cats with a total of 29 electrodes permanently placed in or near the cochlear nucleus, the superior olivary complex, the nucleus of the inferior colliculus, and the medial geniculate body. Detection thresholds for pulsate electrical stimuli were measured using an operant behavioral procedure. Electrical stimulation thresholds were measured prior to and following bilateral destruction of the cochleas in all animals. In addition, four of the animals were tested using a site-of-stimulation discrimination prior to and following the cochlear lesion. Finally, hearing loss was evaluated in all cats after the completion of the experiments. Electrical stimulation thresholds showed a mean reduction of 7.9 dB throughout the brain stem auditory system fater cochlear destruction. The ability of the animals to perform the site-of-stimulation discrimination was not permanently impaired by the cochlear lesion. The data indicated the presence of increased sensitivity to electrical stimulation in most regions of the subcortical auditory system, although a lesser effect was found at the thalamic level. It was concluded that stimulation threshold provides an index relevant to the state of auditory neurons proximal to th...Continue Reading

Citations

Jun 29, 2011·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Panagiota LalakiHenryk Skarzynski
May 16, 2002·Experimental Neurology·J ZhangS J Potashner
Feb 1, 1993·British Journal of Audiology·P J Jastreboff, J W Hazell
Feb 22, 2005·Hearing Research·Aasef G Shaikh, Paul G Finlayson
Jan 27, 2004·Journal of Neuroscience Research·S M MulyS J Potashner
Jul 2, 2003·Journal of Neuroscience Research·Sanoj K Suneja, Steven J Potashner
Aug 5, 2005·Journal of Neurophysiology·John R BartlettWilliam H Overman
Sep 16, 2016·Frontiers in Neural Circuits·Anna R ChambersDaniel B Polley
Jun 9, 2021·Brain Structure & Function·Björn Herrmann, Blake E Butler

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