Central depressant activity of butanol fraction of Securinega virosa root bark in mice

Journal of Ethnopharmacology
M G MagajiI M Hussaini

Abstract

Securinega virosa is a commonly used medicinal plant in African traditional medicine in the management of epilepsy and mental illness. Previous studies in our laboratory showed that the crude methanol root bark extract of the plant possesses significant behavioral effect in laboratory animals. In an attempt to isolate and characterize the biological principles responsible for the observed activity, this study is aimed at evaluating the central depressant activity of the butanol fraction of the methanol root bark extract of Securinega virosa. The medial lethal dose of the butanol fraction was estimated using the method of Lorke. Preliminary phytochemical screening was conducted on the butanol fraction using standard protocol. The behavioral effect of the butanol fraction (75, 150 and 300mg/kg) was evaluated using diazepam induced sleep test, hole-board test, beam walking assay, staircase test, open field test and elevated plus maze assay, all in mice. The median lethal dose of the butanol fraction was estimated to be 1256.9mg/kg. The preliminary phytochemical screening revealed the presence of tannins, saponins, alkaloids, flavonoids, cardiac glycosides, similar to those found in the crude methanol extract. The butanol fraction ...Continue Reading

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Citations

Apr 24, 2014·Journal of Ethnopharmacology·Ben A ChindoAxel Becker
Feb 6, 2015·Oxidative Medicine and Cellular Longevity·Tâmara Coimbra DinizJackson Roberto Guedes da Silva Almeida
Jun 13, 2015·Indian Journal of Pharmacology·Hitender Sharma, Munish Garg
Sep 4, 2014·Asian Pacific Journal of Tropical Biomedicine·Musa Mumammad AliyuMagaji Garba Mohammed
Jan 16, 2020·Journal of Basic and Clinical Physiology and Pharmacology·Afolabi C AkinmoladunM Tolulope Olaleye
Aug 15, 2021·Journal of Ethnopharmacology·Emmanuel Ayodeji AyeniXun Liao

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