Abstract
We investigated the effects of SNC 80 ((+)-4-[alphaR)-alpha-((2S,5R)-4-ally1-2,5-dimethyl-1-pipera zinyl)-3-methoxybenzyl]-N,N-diethylbenzamide), a new highly selective, non-peptidic and systemically active delta-opioid receptor agonist, on gastrointestinal and colonic propulsion in mice. Intraperitoneally (i.p.) SNC 80 (1, 10 and 30 mg/kg) significantly decreased gastrointestinal propulsion measured as transit of an orally administered charcoal meal. Pretreatment with the delta-opioid receptor antagonist, naltrindole (1 mg/kg) subcutaneously (s.c.), with the non-selective opioid antagonist, naloxone (5 mg/kg, s.c.) or the mu1-opioid receptor antagonist, naloxonazine (10 mg/kg, i.p.), significantly decreased the antitransit effect of SNC 80 but pretreatment with the non-selective opioid antagonist, naloxone methiodide (5 mg/kg, s.c.), a quaternary salt of naloxone that does not cross the blood-brain barrier, did not. SNC 80 (1, 5 and 10 mg/kg, i.p.), produced dose-related inhibition of colonic propulsion measured as the increase in mean expulsion time of a 3 mm glass bead placed in the distal colon. Naloxone (5 mg/kg, s.c.) and naltrindole (1 mg/kg, s.c.), completely antagonized the colonic antipropulsive effect of SNC 80. In c...Continue Reading
References
Jun 9, 1977·Nature·J A LordH W Kosterlitz
Sep 1, 1979·Naunyn-Schmiedeberg's Archives of Pharmacology·R SchulzA Herz
Jul 21, 1992·European Journal of Pharmacology·M Broccardo, G Improta
Jul 13, 1990·Neuroscience Letters·R J MilneG D Gamble
Jan 1, 1991·Life Sciences·B KrevskyR S Fisher
Nov 9, 1987·Life Sciences·R B RaffaH I Jacoby
Jan 27, 1988·European Journal of Pharmacology·P S PortogheseA E Takemori
Jan 1, 1988·Life Sciences·T F BurksF Porreca
Sep 23, 1986·European Journal of Pharmacology·G S LingG W Pasternak
Jan 1, 1985·Annual Review of Pharmacology and Toxicology·L Manara, A Bianchetti
Jun 1, 1982·Naunyn-Schmiedeberg's Archives of Pharmacology·J MagnanH W Kosterlitz
Jul 1, 1982·Regulatory Peptides·M BroccardoP Melchiorri
Jan 1, 1995·Peptides·X Y ChaR B Rothman
Aug 1, 1994·Neuropharmacology·G Improta, M Broccardo
Jul 8, 1994·Journal of Medicinal Chemistry·S N CalderonK C Rice
Citations
Oct 5, 2013·European Journal of Medicinal Chemistry·Giovanni LorigaGabriele Murineddu
Jun 14, 2005·Journal of Molecular Graphics & Modelling·Youyi PengWilliam J Welsh
Aug 10, 1999·European Journal of Pharmacology·M BroccardoA Tabacco
Aug 2, 2002·Life Sciences·Alexander A RadzievskyMarvin C Ziskin
Sep 6, 2000·Pharmacology, Biochemistry, and Behavior·A C HutchinsonA L Riley
Mar 4, 2000·Peptides·A L VaccarinoA J Kastin
Dec 22, 1999·British Journal of Pharmacology·L NegriP Melchiorri
Jun 4, 1999·Antisense & Nucleic Acid Drug Development·L NegriS Salvadori
Mar 19, 2008·Clinical and Experimental Pharmacology & Physiology·Andrei SibaevMartin Storr
Jun 23, 2011·Clinical and Experimental Gastroenterology·Glen S PattenMahinda Y Abeywardena
May 8, 2013·Psychopharmacology·Richard M van RijnJennifer L Whistler
Nov 23, 2013·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·David BanjiA R Annamalai
May 31, 2011·Frontiers in Bioscience (Scholar Edition)·Scott M Rawls, Khalid Benamar
Nov 9, 2004·Life Sciences·Kamyar GhaffariAhmad Reza Dehpour
Nov 18, 2006·Neuroscience Letters·Katsumi ShinodaFrank Porreca
Sep 20, 2011·Trends in Pharmacological Sciences·Amynah A PradhanBrigitte L Kieffer
Mar 20, 2012·The Journal of Pain : Official Journal of the American Pain Society·S Stevens NegusKenner C Rice
Aug 19, 2007·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·D ProjeanJ Ducharme
Jan 6, 2004·Medicinal Research Reviews·Masakatsu Eguchi
Jun 22, 2018·American Journal of Physiology. Gastrointestinal and Liver Physiology·Jesse J DiCelloDaniel P Poole
Apr 25, 2006·British Journal of Pharmacology·Francesca BorrelliAngelo A Izzo
Feb 26, 2010·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·M A StorrK A Sharkey
Feb 1, 2019·American Journal of Physiology. Gastrointestinal and Liver Physiology·Simona E CarboneDaniel P Poole
Feb 4, 2012·British Journal of Pharmacology·Angelo A IzzoVincenzo Di Marzo
Nov 27, 2008·American Journal of Physiology. Gastrointestinal and Liver Physiology·Andrei SibaevMartin Storr
Oct 25, 2008·American Journal of Physiology. Gastrointestinal and Liver Physiology·Marnie DuncanKeith A Sharkey
Jun 8, 2012·British Journal of Pharmacology·P R WadeP J Hornby
Mar 25, 2019·Cellular and Molecular Life Sciences : CMLS·Jesse J DiCelloDaniel P Poole
Sep 21, 2018·Frontiers in Pharmacology·Roberta LattanziMariana Spetea
Jun 10, 2005·Basic & Clinical Pharmacology & Toxicology·Elizabeth L Gallantine, Theo F Meert
Jan 11, 2002·Journal of Medicinal Chemistry·Sanjay K SrivastavaJohn W Lewis
May 7, 1999·Journal of Medicinal Chemistry·A CoopK C Rice
Nov 11, 2021·American Journal of Physiology. Gastrointestinal and Liver Physiology·Jesse J DiCelloDaniel P Poole