PMID: 6536902Oct 1, 1984Paper

Central effects of aldosterone infused into the rat subcommissural organ region

Neuroscience Research
R L DundoreW B Severs

Abstract

D-Aldosterone (5 ng/microliter/h) was infused for 6 days into the region of the subcommissural organ (SCO) of conscious, adult male Sprague-Dawley rats. Aldosterone increased urinary sodium loss and the sodium/potassium ratio. Although probably central in origin, these effects still occurred when cannulae were displaced up to 1 mm from the targeted SCO placement. Aldosterone decreased adrenal medullary cross-sectional area without affecting cell density. This effect was highly dependent on proper cannula placement and was not observed when the cannula tip was not in contact with the cerebrospinal fluid of the pineal recess over the rostral two-thirds of the SCO. We conclude that aldosterone increases sodium excretion by an action in the SCO and/or adjacent structures. We also postulate a negative trophic relationship between mineralocorticoids and the adrenal medulla mediated by the SCO.

Citations

Oct 24, 1994·Neuroscience Letters·C D BalabanW B Severs
Oct 31, 1998·Brain Research. Molecular Brain Research·A C RobsonM C Holmes
Mar 6, 2009·American Journal of Physiology. Renal Physiology·Joel C Geerling, Arthur D Loewy
Dec 2, 2005·The Journal of Comparative Neurology·Joel C GeerlingArthur D Loewy
Nov 30, 2012·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Silmara FormentiEduardo Colombari
May 14, 1998·Microscopy Research and Technique·E M RodríguezS Hein

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