PMID: 1212558Dec 1, 1975Paper

Central effects of clonidine 2-(2,6-dichlorophenylamino)-2-imidazoline hydrochloride in fowls

British Journal of Pharmacology
E Marley

Abstract

1 The effects of clonidine infused into the IIIrd cerebral ventricle, the hypothalamus or intravenously were studied on behaviour, electrocortical activity, body, comb and leg temperatures, respiration and carbon dioxide elimination in adult and young fowls (Gallus domesticus). 2 Behavioural and electrocortical slow wave sleep were induced by clonidine infused into IIIrd cerebral ventricle, the hypothalamus or intravenously. Suprisingly, sleep elicited by intravenous clonidine was much longer-lasting than that induced by an identical dose given intraventricularly. 3 Body temperature was lowered by clonidine given intraventricularly or infused into the hypothalamus. Depending on initial comb temperature and ambient temperature, comb temperature was elevated, unaffected or lowered as body temperature fell; temperature of the unfeathered legs also rose as body temperature declined after clonidine. 4 Following clonidine, but before any considerable decline of body temperature, tachypnoea and wing abduction developed; during recovery of body temperature, the wings were lowered and applied closely to the trunk and the feathers partly erected. 5 CO2 elimination fell more swiftly than body temperature following intrahypothalamic clonid...Continue Reading

References

Jan 1, 1975·British Journal of Pharmacology·E Marley, J E Whelan
Feb 1, 1975·British Journal of Pharmacology·E Marley, G Nistiò
Jun 1, 1973·European Journal of Pharmacology·B Delbarre, H Schmitt
Dec 1, 1971·British Journal of Pharmacology·R B HolmanM Vogt
Dec 1, 1972·British Journal of Pharmacology·E Marley, G Nistico
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Jul 1, 1974·British Journal of Pharmacology·E Marley, T J Seller
Jul 1, 1974·British Journal of Pharmacology·E Marley, T J Seller
Mar 1, 1972·British Journal of Pharmacology·E Marley, T J Seller
Jan 1, 1967·Ceskoslovenská fysiologie·R A McCance
Dec 1, 1970·British Journal of Pharmacology·E Marley, J D Stephenson
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Citations

Dec 1, 1981·Naunyn-Schmiedeberg's Archives of Pharmacology·P JohanssonM Henning
Dec 16, 1977·European Journal of Clinical Pharmacology·A AutretH Schmitt
Aug 1, 1978·European Journal of Pharmacology·G NisticòJ D Stephenson
Feb 1, 1976·Pharmacological Research Communications·G NisticòP Preziosi
Jan 1, 1993·Brain Research Bulletin·A A RomanovskyC M Blatteis
Jan 1, 1980·Progress in Neuro-psychopharmacology·A Elizur, Z Liberson
Feb 1, 1992·Antimicrobial Agents and Chemotherapy·A P RickettsJ R Rice
Jan 1, 1981·Medicinal Research Reviews·S Fielding, H Lal

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