Abstract
1 The primary aim was to study the central respiratory effects of cannabinoids (CB). To this end, the cannabinoid receptor agonist WIN55212-2 was injected into the cisterna magna of urethane-anaesthetised rats and changes in respiratory parameters were observed. The secondary aim was to observe the centrally elicited cardiovascular actions of WIN55212-2. Involvement of opioid mechanisms in the central effects of WIN55212-2 was also studied. 2 Intracisternal (i.c.) application of WIN55212-2 (1, 3, 10 and 30 microg kg(-1)) dose-dependently decreased the respiratory rate and minute volume. Tidal volume was slightly increased, whereas peak inspiratory flow remained unchanged. In addition, WIN55212-2 increased mean arterial pressure and the plasma noradrenaline concentration and decreased heart rate. 3 I.c. injection of WIN55212-3 (1, 3, 10 and 30 microg kg(-1)), an enantiomer of WIN55212-2 lacking affinity for cannabinoid receptors, elicited no effects. All effects of WIN55212-2 were prevented by the CB1 receptor antagonist SR141716 (2 mg kg(-1) i.v.). I.c. administration of the opioid receptor agonist DAMGO (0.1, 0.3, 1 and 3 microg kg(-1)) markedly lowered the respiratory rate, tidal volume, minute volume and peak inspiratory flo...Continue Reading
References
Jul 1, 1976·Life Sciences·I R Moss, E Friedman
Jan 1, 1992·Neuroscience·P Mailleux, J J Vanderhaeghen
Jul 6, 1987·Life Sciences·U EstradaW L Dewey
Mar 1, 1974·The Journal of Pharmacy and Pharmacology·R R VollmerJ P Buckley
Jun 1, 1973·European Journal of Pharmacology·I CaveroB S Jandhyala
Sep 1, 1973·British Journal of Pharmacology·J D Graham, D M Li
Aug 22, 1994·FEBS Letters·M Rinaldi-CarmonaD Caput
Jun 1, 1993·Biulleten' eksperimental'noĭ biologii i meditsiny·I A TarakanovV A Safonov
Jan 22, 1993·The Journal of Comparative Neurology·L A MatsudaS J Lolait
Oct 1, 1996·Hypertension·K VargaG Kunos
Jun 27, 1997·Science·G TandaG Di Chiara
Aug 1, 1997·Naunyn-Schmiedeberg's Archives of Pharmacology·B MalinowskaE Schlicker
Feb 14, 1998·Neuroscience·K TsouJ M Walker
Mar 1, 1997·Neuroscience·M GlassR L Faull
Dec 10, 1998·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·J A WagnerG Kunos
Mar 17, 1999·British Journal of Pharmacology·N Niederhoffer, B Szabo
Apr 29, 2000·Prostaglandins & Other Lipid Mediators·G KunosJ A Wagner
Jul 15, 2000·British Journal of Anaesthesia·C K Pac-SooJ G Whitwam
Aug 25, 2001·Naunyn-Schmiedeberg's Archives of Pharmacology·B MalinowskaE Schlicker
Sep 21, 2001·British Journal of Pharmacology·B SzaboK Wedzony
Nov 13, 2001·Anaesthesia·R N KumarR G Pertwee
Dec 1, 2001·European Journal of Pharmacology·E S ViziT F Freund
May 31, 2002·Pharmacological Reviews·A C HowlettR G Pertwee
Jan 11, 2003·American Journal of Physiology. Heart and Circulatory Physiology·David J RademacherJeanne L Seagard
Apr 24, 2003·Naunyn-Schmiedeberg's Archives of Pharmacology·Nathalie NiederhofferBela Szabo
Sep 13, 2003·British Journal of Pharmacology·James R PadleyAnn K Goodchild
Sep 19, 2003·Naunyn-Schmiedeberg's Archives of Pharmacology·Karin SchmidBela Szabo
Citations
Sep 29, 2011·The Journal of Pharmacology and Experimental Therapeutics·Badr Mostafa Ibrahim, Abdel A Abdel-Rahman
Mar 1, 2012·The Journal of Pharmacology and Experimental Therapeutics·Badr Mostafa Ibrahim, Abdel A Abdel-Rahman
Sep 14, 2006·Pharmacological Reviews·Pál PacherGeorge Kunos
Jan 12, 2013·PloS One·András IringZoltán Benyó
Jan 18, 2006·Biomedical Research·Shusuke KodaAtsuhiro Sakamoto
Jul 26, 2008·Naunyn-Schmiedeberg's Archives of Pharmacology·Hester van DiepenMartin C Michel
Apr 1, 2014·Peptides·Xu-hui LiQuan Fang
Apr 10, 2009·Seminars in Immunopathology·Pál Pacher, Sabine Steffens
May 28, 2013·Journal of Pain and Symptom Management·Paul HowardAndrew Wilcock
Aug 31, 2010·Neuroscience·K TreeF Cayetanot
Apr 27, 2005·British Journal of Pharmacology·Juha R SavinainenJarmo T Laitinen
May 12, 2006·Journal of Neurochemistry·Joseph F CheerR Mark Wightman
Aug 16, 2011·Brain Research·Badr Mostafa Ibrahim, Abdel A Abdel-Rahman
Jul 26, 2005·Peptides·Richard J Bodnar, Gad E Klein
Feb 17, 2015·Journal of Advanced Research·Badr M Ibrahim, Abdel A Abdel-Rahman
Nov 16, 2010·Behavioural Brain Research·Paolo LazzariLuca Pani
Jun 3, 2016·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Simon L HillSimon H L Thomas
Sep 24, 2016·Naunyn-Schmiedeberg's Archives of Pharmacology·Emilia GrzędaBarbara Malinowska
Nov 20, 2016·Journal of Hypertension·Tao WangQian Li
Jun 10, 2016·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Caron DeanQuinn H Hogan
Dec 18, 2004·American Journal of Physiology. Heart and Circulatory Physiology·S M GardinerT Bennett
Jan 13, 2006·British Journal of Pharmacology·Takayuki Endoh
Oct 26, 2011·British Journal of Pharmacology·Barbara MalinowskaEberhard Schlicker
Jan 31, 2016·American Journal of Physiology. Heart and Circulatory Physiology·Zoltán BenyóPál Pacher
Mar 7, 2020·Clinical and Experimental Pharmacology & Physiology·Takahiro ShimizuMotoaki Saito
Jun 27, 2020·Journal of Cardiovascular Pharmacology and Therapeutics·John R Richards
Jul 1, 2015·Current Opinion in Supportive and Palliative Care·Sarah Awan, Andrew Wilcock
Nov 19, 2019·Frontiers in Neuroscience·Sabrine BilelMatteo Marti
Mar 2, 2018·Journal of Hypertension·Guo-Qi LiQian Li
May 29, 2018·European Journal of Pharmacology·Peter F WeedCharles P France