PMID: 2497207Feb 1, 1989Paper

Central giant cell granulomas of the jaws. Nuclear DNA analysis using image cytometry

International Journal of Oral and Maxillofacial Surgery
A EckardtB H Mayall

Abstract

Giant cell nuclear DNA, in 30 giant cell lesions of the jaws, was quantified by computer-assisted image analysis. DNA content was then used to predict clinical behavior and outcome. 4 nuclei in each of 25 giant cells (total = 100 nuclei) were randomly selected and the DNA content was quantified by the Leitz Texture-Analysis-System-Plus. DNA in nuclei of normal appearing stromal fibroblasts (n = 20) was similarly measured. The DNA index was calculated as the mean nuclear DNA content of giant cells divided by the mean DNA content of control fibroblasts. The mean DNA-index of aggressive lesions (1.09, SD = 0.12) was not significantly different from that of non-aggressive lesions (1.18, SD = 0.15) (p = 0.093). The results indicate that the nuclear DNA content of giant cells is not useful as a predictor of the clinical behavior of giant cell lesions of the jaws.

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Citations

Mar 1, 1994·Head & Neck·J P StolovitzkyF M McConnel
Oct 27, 2012·Irish Journal of Medical Science·J E O'Connell, G J Kearns
Dec 13, 2000·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·P DahlkemperM L Hicks
Jun 13, 2001·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·M KurtzP Alberto
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Mar 14, 2013·Annals of Maxillofacial Surgery·Anthony M Pogrel
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Mar 1, 2006·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Birgit Kruse-LöslerJohannes Kleinheinz
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Aug 8, 2020·The Cleft Palate-craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association·Nima KhavaninJordan P Steinberg
Jun 11, 2003·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·M A Pogrel
May 13, 1999·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·W R WalstadS J McKenna
Jul 23, 1999·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·M A PogrelS R Goldring
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