Central giant cell granulomas of the jaws: phenotype and proliferation-associated markers

Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
M O'MalleyJ A Regezi

Abstract

Central giant cell granulomas (CGCGs) are jaw tumors of unknown origin that often exhibit an aggressive, though unpredictable, clinical course. The purpose of this study was to determine the immunoprofile of the mononuclear cells that seem to be responsible for the biologic behavior of these tumors. Numbers of cells in cell cycle were also determined and compared in clinically aggressive and non-aggressive CGCGs. Sixteen aggressive and 12 non-aggressive CGCGs were immunohistochemically stained with antibodies to CD34, CD68, factor XIIIa, alpha-smooth muscle actin, prolyl 4-hydroxylase, Ki-67, and p53 protein. Cell populations and numbers of cells in cell cycle were determined through microscopic quantitative assessment. CD34-positive cells were limited to support vessels. CD68-positive mononuclear cells constituted a small population of cells in all tumors. With two exceptions, factor XIIIa-positive cells were rarely seen. Alpha-smooth muscle actin staining was present in approximately half the tumors, and occasionally large numbers of positive cells were seen. Most mononuclear cells were positive for fibroblast-associated antigen. No phenotypic differences were detected between aggressive and non-aggressive tumors. P53 protein...Continue Reading

References

Dec 8, 1977·Virchows Archiv. A, Pathological Anatomy and Histology·T AparisiJ L Ericsson
Feb 1, 1989·International Journal of Oral and Maxillofacial Surgery·A EckardtB H Mayall
Aug 1, 1988·Oral Surgery, Oral Medicine, and Oral Pathology·P L AuclairG L Ellis
Sep 1, 1986·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·R ChuongA Perez-Atayde
Jul 1, 1987·Oral Surgery, Oral Medicine, and Oral Pathology·G FicarraL S Hansen
Jun 15, 1984·European Journal of Biochemistry·M HöyhtyäK Tryggvason
Feb 1, 1995·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·L Lim, J R Gibbins
Jul 1, 1994·Journal of Cellular Biochemistry·D Robinson, T A Einhorn
Mar 10, 1994·Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine·K Abe
Feb 1, 1993·Oral Surgery, Oral Medicine, and Oral Pathology·S B Whitaker, C A Waldron
Jan 1, 1953·Journal of Oral Surgery·A BERGER, H L JAFFE
Jan 1, 1953·Oral Surgery, Oral Medicine, and Oral Pathology·H L JAFFE

❮ Previous
Next ❯

Citations

Mar 19, 2013·Journal of Molecular Histology·Renato Luiz Maia NogueiraSilvia Helena Barem Rabenhorst
Oct 27, 2012·Irish Journal of Medical Science·J E O'Connell, G J Kearns
Aug 1, 2009·Head and Neck Pathology·Elizabeth BilodeauBobby Collins
Jun 28, 2011·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Fabrício Rezende AmaralCarolina Cavaliéri Gomes
Jan 22, 2004·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Joseph A Regezi
Oct 27, 1999·International Journal of Oral and Maxillofacial Surgery·J de LangeH van den Berg
Jun 13, 2001·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·M KurtzP Alberto
Feb 28, 2002·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Roman Carlos, Heddie O Sedano
Oct 28, 2003·The Cleft Palate-craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association·Yoshimichi ImaiAtsushi Yamada
Dec 11, 2002·Neurologia Medico-chirurgica·Junichi YoshimuraHitoshi Takahashi
Mar 14, 2013·Annals of Maxillofacial Surgery·Anthony M Pogrel
Oct 10, 2014·National Journal of Maxillofacial Surgery·Suresh YadavShallu Tyagi
Dec 27, 2015·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Rodrigo Gadelha VasconcelosLélia Maria Guedes Queiroz
Mar 1, 2012·International Journal of Oral and Maxillofacial Surgery·R L M NogueiraS H B Rabenhorst
Nov 23, 2011·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Zachary S PeacockBrian L Schmidt
Mar 23, 2011·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Antonia KolokythasMichael Miloro
Jan 7, 2011·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·Nadia Theologie-LygidakisIoannis Iatrou
Aug 10, 2010·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Sarah K WestburyStephen R Watt-Smith
Aug 17, 2010·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Petr SchützBonnie L Padwa
Apr 25, 2009·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Regina LandesbergEthel Siris
Apr 21, 2009·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Srinivas M SusarlaThomas B Dodson
Apr 22, 2008·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Nathan C DewsnupMeredith August
Sep 6, 2015·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·John Edward O'ConnellGerard J Kearns
Aug 10, 2007·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Marilena VeredDan Dayan
Oct 30, 2010·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·N TorabiniaZ Shokrolahi
Jan 5, 2011·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Felipe R MatosRoseana de A Freitas
Mar 19, 2016·Journal of Investigative and Clinical Dentistry·Gargi S SarodePrakash Patil
Mar 24, 2016·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·David JerkinsMukund Dole
Oct 12, 2013·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Sachin C Sarode, Gargi S Sarode
Oct 16, 2015·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Nancy Noya MaizMaría Esther Irigoyen Camacho
May 13, 1999·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·W R WalstadS J McKenna
Apr 6, 2006·International Journal of Oral and Maxillofacial Surgery·J de LangeR A Th Gortzak
Jul 11, 2006·International Journal of Oral and Maxillofacial Surgery·J de LangeH Klip
Mar 1, 2006·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Birgit Kruse-LöslerJohannes Kleinheinz
Jul 21, 2015·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Allisson Filipe Lopes MartinsElismauro Francisco Mendonça
Jul 16, 2013·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Fabrício Rezende AmaralCarolina Cavaliéri Gomes
Feb 12, 2000·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·H OkadaH Yamamoto
Jun 11, 2003·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·M A Pogrel
Feb 27, 2008·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Gloria Amparo Flórez-MorenoSergio Iván Tobón-Arroyave
Aug 1, 2007·Journal of Applied Oral Science : Revista FOB·Maria do Socorro AragãoLeão Pereira Pinto
Apr 27, 2004·Periodontology 2000·Christopher W Cutler, Ravi Jotwani
Apr 9, 2005·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Paulo Eduardo Alencar de SouzaWalderez Ornelas Dutra
May 26, 2005·The Journal of Craniofacial Surgery·Francesco CarinciFurio Pezzetti
Mar 6, 2010·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Donia SadriAghdas Forouzandeh
Mar 21, 2002·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Joseph A Regezi
May 1, 2012·Virchows Archiv : an International Journal of Pathology·F HemingwayN A Athanasou

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons
R ChuongA Perez-Atayde
Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons
J C Tiffee, T B Aufdemorte
Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons
M A PogrelS R Goldring
Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
M VeredD Dayan
© 2021 Meta ULC. All rights reserved