Central giant cell lesion of the jaws: An updated analysis of 2270 cases reported in the literature

Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
Bruno Ramos ChrcanovicRicardo Santiago Gomez

Abstract

To review all available data published on central giant cell lesion (CGCL) of the jaws into a comprehensive analysis of its clinical/radiological features, with emphasis on the predictive factors associated with its recurrence. An electronic search was undertaken in 5 databases (February/2018), looking for reporting cases of CGCLs. A total of 365 publications were included, comprising 2270 lesions. CGCLs were more prevalent in women and the mandible. Cortical bone perforation occurred in 50% of the cases. Marginal/segmental resection was more often performed in larger lesions, and drug therapy was more frequent in small lesions. Recurrence was reported in 232 of 1316 cases (17.6%). The recurrence rate of the aggressive lesions (22.8%) after surgical treatment was higher than non-aggressive lesions (7.8%). Four of 5 CGCLs showed partial/total regression with pharmacological treatment. Aggressive lesions showed a worse response to corticosteroids than non-aggressive lesions. For the lesions submitted to surgery as the first treatment, curettage, enucleation, or marginal resection in relation to segmental resection, aggressive lesions, cortical bone perforation, and tooth root resorption were associated with increased recurrence r...Continue Reading

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Citations

Sep 27, 2018·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Bruno Ramos Chrcanovic, Ricardo Santiago Gomez
Jan 17, 2019·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Bruno Ramos ChrcanovicRicardo Santiago Gomez
Jul 30, 2019·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Bruno Ramos ChrcanovicRicardo Santiago Gomez
Nov 6, 2018·Nature Communications·Carolina Cavalieri GomesNada Jabado
Nov 11, 2019·The Journal of Pathology·Carolina C GomesRicardo S Gomez
Jan 18, 2020·Head and Neck Pathology·Jen-Chieh Lee, Hsuan-Ying Huang
Jan 21, 2021·Special Care in Dentistry : Official Publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry·José Alcides Almeida de ArrudaElismauro Francisco Mendonça
Jan 15, 2021·International Journal of Surgery Case Reports·Ouassime KerdoudFaiçal Slimani
Mar 9, 2021·The Neuroradiology Journal·Ahmed Abdel Khalek Abdel Razek
Mar 25, 2021·Special Care in Dentistry : Official Publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry·Bruno Augusto Linhares Almeida MarizAndré Caroli Rocha
Apr 17, 2021·Journal of Clinical Pathology·Atif Ahmed, Aparna Naidu
Aug 20, 2021·Journal of Stomatology, Oral and Maxillofacial Surgery·Jordan RichardsonElizabeth Philipone
Oct 3, 2021·Clinical Oral Investigations·Camila Camarini, Elen de Souza Tolentino
Nov 14, 2021·International Forum of Allergy & Rhinology·Samyuktha MelachuriCarl H Snyderman

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