Central hemodynamics during lung recruitment maneuvers at hypovolemia, normovolemia and hypervolemia. A study by echocardiography and continuous pulmonary artery flow measurements in lung-injured pigs

Intensive Care Medicine
Jonas NielsenAnders Larsson

Abstract

The impact of lung-recruitment maneuvers on heart function at different volemic levels has not been studied in detail. We therefore investigated the effect on central hemodynamics of lung recruitment maneuvers at hypovolemia, normovolemia and hypervolemia in experimental lung injury. Randomized, controlled, cross-over experimental study. Animal laboratory at a university hospital. Eleven anesthetized and lung-lavaged pigs. The animals were randomized to 10-s lung recruitment maneuvers followed by 30-s maneuvers (40 cm H(2)O airway pressure) or vice versa, performed under hypovolemia, normovolemia and hypervolemia. Left-ventricular end-diastolic diameter and cardiac output were measured before, during, and 1 min and 5 min after the lung recruitment maneuver and left-ventricular eccentricity index was calculated for before and during the maneuver. Cardiac output and left-ventricular end-diastolic diameter (within parentheses) decreased significantly during both the 10-s and 30-s lung recruitment maneuvers at hypovolemia, by a mean of 89% (35) and 92% (33), at normovolemia by 75% (33) and 86% (32), and at hypervolemia by 56% (32) and 64% (43), respectively. At hypovolemia, cardiac output was increased above baseline 1-5 min follow...Continue Reading

References

Jan 1, 1989·Comparative Biochemistry and Physiology. A, Comparative Physiology·J H Cissik, W J Ehler
Mar 1, 1986·Mayo Clinic Proceedings·R A Nishimura, A J Tajik
Apr 1, 1985·Journal of the American College of Cardiology·T RyanW F Armstrong
Feb 12, 1981·The New England Journal of Medicine·F JardinJ P Bourdarias
Dec 1, 1993·British Journal of Anaesthesia·H U RothenG Hedenstierna
Apr 16, 1998·Journal of Applied Physiology·M MaggioriniR Naeije
Aug 6, 1998·British Journal of Anaesthesia·L MagnussonG Hedenstierna
Oct 7, 1998·Journal of Applied Physiology·P NeumannG Hedenstierna
Nov 24, 1999·Journal of Applied Physiology·A Vieillard-BaronF Jardin
Jul 10, 2003·Intensive Care Medicine·J ClaessonO Winsö
Jan 1, 1962·Medicina Thoracalis·S PERMUTTH N BANE
Mar 19, 1955·British Medical Journal·E P SHARPEY-SCHAFER
Apr 24, 2004·Anesthesia and Analgesia·Silvia NunesStephan M Jakob
Dec 16, 2004·Critical Care Medicine·Sung-Chul LimJohn J Marini
Dec 18, 2004·Intensive Care Medicine·Helena OdenstedtStefan Lundin
Aug 13, 2005·Intensive Care Medicine·Jonas NielsenAnders Larsson
Jun 10, 1966·Science·L K Bustad, R O McClellan

❮ Previous
Next ❯

Citations

Dec 3, 2011·American Journal of Respiratory Cell and Molecular Biology·Armand Mekontso DessapJoe G N Garcia
May 18, 2011·Critical Care : the Official Journal of the Critical Care Forum·Gilles RivalGilles Capellier
Apr 21, 2009·Critical Care : the Official Journal of the Critical Care Forum·Christian GernothThomas Luecke
Apr 30, 2010·Critical Care : the Official Journal of the Critical Care Forum·Jean-Michel ConstantinJean-Etienne Bazin
Jul 9, 2010·Best Practice & Research. Clinical Anaesthesiology·Gerardo Tusman, Stephan H Böhm
Dec 20, 2008·Acta Anaesthesiologica Scandinavica·C K MarumoJ O C Auler
Apr 19, 2008·Acta Anaesthesiologica Scandinavica·J Koefoed-NielsenA Larsson
Nov 3, 2010·Acta Anaesthesiologica Scandinavica·K LowhagenS Lundin
Dec 19, 2015·BioMed Research International·András Lovas, Tamás Szakmány
Apr 1, 2014·Paediatric Respiratory Reviews·Jacqui Jauncey-CookeFiona Bogossian
Oct 23, 2009·Journal of Intensive Care Medicine·Kwang Joo ParkSung Chul Hwang
Jan 9, 2020·Journal of Anesthesia·Koichi Suehiro
Jul 14, 2020·American Journal of Physiology. Gastrointestinal and Liver Physiology·Shengchen LiuStephan M Jakob
Jul 10, 2021·Medicina Intensiva·M LomeliJ Mancebo
May 4, 2020·Medicina intensiva·Manuel LomeliJordi Mancebo

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.