Central hypothyroidism with oxcarbazepine therapy

Pediatric Neurology
Jennifer Miller, Paul Carney

Abstract

Abnormalities in thyroid function with the use of several antiepileptic medications are thought to result from increased metabolism of thyroid hormone and interference with the hypothalamic-pituitary axis. Oxcarbazepine was developed to attempt to reduce the side effects that have traditionally been observed with antiepileptic drugs that induce the hepatic enzyme system. Increased metabolism of thyroid hormone should not occur in patients on oxcarbazepine as the hepatic enzyme system has minimal involvement in the metabolism of this medication. This report describes three patients who developed central hypothyroidism associated with oxcarbazepine treatment, suggesting that oxcarbazepine interferes with the hypothalamic-pituitary axis.

References

Jan 1, 1992·Epilepsia·J I IsojärviV V Myllylä
Jun 1, 1993·Acta Paediatrica Japonica; Overseas Edition·A YükselA Cenani
Aug 3, 2001·Pediatric Neurology·A VerrottiF Chiarelli
Sep 24, 2004·Epilepsy & Behavior : E&B·Dieter Schmidt, Christian E Elger

❮ Previous
Next ❯

Citations

Mar 3, 2010·CNS Drugs·Dean P Sarco, Blaise F D Bourgeois
Oct 6, 2015·Expert Review of Clinical Pharmacology·Sherifa Ahmed Hamed
Nov 28, 2009·Best Practice & Research. Clinical Endocrinology & Metabolism·Bryan R Haugen
Jun 17, 2008·Pediatric Neurology·Anne M ComiEmily L Germain-Lee
Jun 10, 2008·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Burç C PoyrazIbrahim Balcioğlu
Jun 6, 2014·The Lancet. Diabetes & Endocrinology·Rosa Maria ParagliolaRoberto Salvatori
Oct 5, 2013·Seizure : the Journal of the British Epilepsy Association·Unsal YılmazHasan Tekgül
May 27, 2016·Bipolar Disorders·Christophe G LambertBerit Kerner
Mar 25, 2016·Epilepsy Research·Anastasia GaroufiAlexandra Soldatou
May 27, 2017·Nature Reviews. Endocrinology·Paolo Beck-PeccozAndrea Lania
Nov 1, 2012·Journal of Child Neurology·Laila SiddiqueEmily L Germain-Lee
Sep 9, 2018·Acta Neurologica Scandinavica·Margret Jona EinarsdottirHelga Agusta Sigurjonsdottir
Jul 26, 2019·Current Opinion in Endocrinology, Diabetes, and Obesity·An JacobsGreet Van den Berghe
Nov 21, 2019·Journal of the Endocrine Society·Lies LangoucheGreet Van den Berghe
Oct 9, 2020·Journal of Child Neurology·Bahareh Michelle SchweigerJane Tavyev

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience
Andrew M ArnoldNorman L Eberhardt
Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
D BonguU M Kabadi
© 2021 Meta ULC. All rights reserved