Central infusion of ovine CRF (oCRF) potentiates defensive behaviors in CD-1 mice in the Mouse Defense Test Battery (MDTB).

Behavioural Brain Research
Mu YangD C Blanchard

Abstract

Following intracerebroventricular (i.c.v.) injection of ovine CRF (oCRF), an endogenous peptide agonist at both CRF1 and CRF2 receptors, defensive behaviors of CD-1 mice were evaluated in the Mouse Defensive Test Battery (MDTB). Behavioral measures taken before, during, and after predator (a hand-held anesthetized rat) confrontation included exploratory activity, risk assessment, avoidance, flight, freezing, defensive threat/attack, and residual emotional responses. Both low (0.1 nmol) and high (0.2 nmol) doses of oCRF robustly suppressed exploratory activities and increased risk assessment during the initial familiarization period. Flight speed and jump escapes when the mouse was chased were significantly elevated by the 0.2 nmol dose. Both doses enhanced freezing and avoidance to a distant predator when the escape route was blocked. The 0.2 nmol dose also potentiated flight responses to a contacting predator in a highly confined space. Both oCRF groups traveled shorter distances and exhibited less escape attempts following the removal of the threat stimulus. These findings indicate that non-selective activation of corticotropin-releasing factor (CRF) receptors via ventricular infusion of oCRF potentiates defensive behaviors r...Continue Reading

References

Dec 31, 1997·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·R J PrimusD W Gallager
Dec 17, 1998·Physiology & Behavior·R J BlanchardS Parmigiani
Dec 2, 1999·Neuroscience and Biobehavioral Reviews·S ParmigianiP F Ferrari
Nov 7, 2000·The Journal of Comparative Neurology·K Van PettP E Sawchenko
Apr 20, 2001·Brain Research. Molecular Brain Research·S P HoS P Arneric
May 30, 2001·Neuroscience and Biobehavioral Reviews·D C BlanchardR J Blanchard
Sep 27, 2001·Endocrinology and Metabolism Clinics of North America·K E HabibG P Chrousos
Jan 22, 2002·Neuroscience and Biobehavioral Reviews·L K Takahashi
Jan 23, 2003·The Journal of Pharmacology and Experimental Therapeutics·David A GutmanCharles B Nemeroff
Feb 26, 2003·European Journal of Pharmacology·D Caroline BlanchardRobert J Blanchard
Jun 6, 2003·Progress in Neuro-psychopharmacology & Biological Psychiatry·Cecile DucottetCatherine Belzung
Dec 9, 2003·Progress in Neuro-psychopharmacology & Biological Psychiatry·D Caroline BlanchardRobert J Blanchard
Jan 28, 2004·Annual Review of Pharmacology and Toxicology·Tracy L Bale, Wylie W Vale
Mar 10, 2004·Pharmacology, Biochemistry, and Behavior·B M CampbellK M Merchant
Apr 23, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jie LiuJoel P Gallagher
Jun 12, 2004·Proceedings of the National Academy of Sciences of the United States of America·Hossein TezvalJoachim Spiess
Aug 7, 2004·The Journal of Pharmacology and Experimental Therapeutics·Stephen C Heinrichs, George F Koob
Nov 13, 2004·The Journal of Pharmacology and Experimental Therapeutics·Oliver StiedlJoachim Spiess
May 19, 2005·Neuroscience and Biobehavioral Reviews·Martin E KeckMarianne B Müller
Aug 9, 2005·Neuroscience and Biobehavioral Reviews·D Caroline BlanchardRobert J Blanchard
Aug 16, 2005·Neuroscience and Biobehavioral Reviews·Cedomir TodorovicJoachim Spiess
Aug 27, 2005·Neuroscience and Biobehavioral Reviews·E R Ribeiro-BarbosaD C Blanchard

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Citations

May 3, 2008·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Laura M HodgesSteven P Hamilton
Apr 23, 2013·Hormones and Behavior·Karina G BorelliMarcus L Brandão
Nov 25, 2018·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Lara S HwaThomas L Kash
Nov 11, 2006·Behavioural Brain Research·Eduardo F Carvalho-NettoRobert J Blanchard
May 18, 2021·Neurobiology of Stress·Wayne J Korzan, Cliff H Summers

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