Central infusion of vasopressin in male rats accelerates extinction of conditioned taste avoidance induced by LiCl

Brain Research Bulletin
Unja L Hayes, Kathleen C Chambers

Abstract

In shock avoidance tasks, extinction is prolonged when vasopressin is infused into the lateral ventricle after an acquisition session. Experiments were performed to determine whether a dose of vasopressin that does not induce conditioned taste avoidance (CTA) could prolong extinction of a LiCl-induced CTA when it is infused into the lateral ventricle of Sprague-Dawley male rats after acquisition. The first experiment was designed to determine whether infusion of vasopressin into the lateral ventricle would induce a CTA. Consumption of a sucrose solution was paired with infusion of vasopressin or saline, and even after two pairings, none of the vasopressin-treated rats showed decreases in sucrose consumption. Therefore, in the second experiment, this same dose of vasopressin was infused into the lateral ventricle 50 min after consumption of a sucrose solution was paired with an injection of LiCl. Vasopressin increased the rate of extinction of the LiCl-induced CTA. These results are the opposite of what has been found after peripheral administration of vasopressin before acquisition and/or extinction of a LiCl-induced CTA. Possible reasons for the difference in the direction of the effect on extinction include differential effec...Continue Reading

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Citations

Jan 12, 2005·Physiology & Behavior·UnJa L Hayes, Kathleen C Chambers
Feb 24, 2015·Frontiers in Endocrinology·Janet K Bester-MeredithGrace E Mammarella

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