PMID: 3767070Sep 1, 1986Paper

Central inhibition of sympathetic overdrive by clonidine in acute myocardial infarction with systolic hypertension. Haemodynamic study

Angiology
M RenardR Bernard

Abstract

Intravenous clonidine was used to treat systolic hypertension (systolic blood pressure greater than 160 mm Hg) in 15 patients with acute myocardial infarction and documented sympathetic overactivity (high plasma norepinephrine). Its effects on haemodynamics and blood gases were studied. After one hour, clonidine significantly reduced the systolic (195 +/- 7 to 137 +/- 7 mm Hg, p less than 0.01) and diastolic (81 +/- 4 to 60 +/- 3 mm Hg, p less than 0.01) blood pressures as well as the systemic vascular resistance (26 +/- 2 to 20 +/- 1 IU, p less than 0.01). The cardiac index was reduced from 2.8 +/- 0.2 to 2.4 +/- 0.2 l/min X m2, p less than 0.01. This change was related to a reduction of the heart rate (92 +/- 4 to 81 +/- 4 beats/min, p less than 0.01) as the stroke index was unchanged. Pulmonary wedge pressure (15 +/- 3 to 10 +/- 2 mm Hg, p less than 0.01) and rate pressure product (18.034 +/- 1.159 to 11.274 +/- 917 mm Hg, beats/min, p less than 0.01) were also significantly decreased. The arterial oxygen tension did not change significantly but there was a significant drop in the mixed venous oxygen saturation (63 +/- 2 to 61 +/- 2%, p less than 0.02) and oxygen transport (433 +/- 41 to 409 +/- 36, p less than 0.01). Clonid...Continue Reading

References

Nov 1, 1979·American Heart Journal·R A Nadeau, J de Champlain
Oct 1, 1978·American Heart Journal·T C Gibson
Aug 16, 1975·British Medical Journal·M F Oliver
Sep 5, 1974·The New England Journal of Medicine·W E Shell, B E Sobel
Jan 1, 1984·Journal of Cardiovascular Pharmacology·M RenardR Bernard
Aug 1, 1984·International Journal of Cardiology·R J Zochowski, W Lada
Mar 1, 1983·The American Journal of Cardiology·J B HermillerC V Leier
Dec 1, 1980·European Heart Journal·A D TimmisD A Chamberlain
Jul 1, 1980·Circulation Research·S WallensteinJ L Fleiss
Apr 1, 1979·British Journal of Clinical Pharmacology·P G Marx, D S Reid

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