Central insulin inhibits hypothalamic galanin and neuropeptide Y gene expression and peptide release in intact rats

Brain Research
J Wang, K L Leibowitz

Abstract

The central actions of insulin, on galanin (GAL) and neuropeptide Y (NPY) in the brain, are examined in intact satiated rats. Ventricular injections of insulin reduce both GAL and NPY gene expression and immunoreactivity in different hypothalamic areas but have no effect in extra-hypothalamic sites. Insulin applied to medial hypothalamic fragments in vitro significantly reduces GAL and NPY release. This evidence suggests that insulin acts centrally and directly on hypothalamic peptide activity under normal feeding conditions.

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Citations

Jun 24, 2003·Physiology & Behavior·Sarah F LeibowitzBartley G Hoebel
Aug 20, 2011·Proceedings of the National Academy of Sciences of the United States of America·Erin C Hanlon, Eve Van Cauter
Sep 18, 1998·Current Opinion in Lipidology·J A HarroldG Williams
Feb 3, 1999·Annals of the New York Academy of Sciences·S F Leibowitz
Mar 17, 2004·Molecular and Cellular Biology·J G HohmannR A Steiner
Jan 2, 2003·Journal of Endocrinological Investigation·R VettorG Federspil
Feb 19, 2008·Regulatory Peptides·D StevanovićW B Severs
Sep 5, 1998·Brain Research·J WangS F Leibowitz
Feb 9, 2012·Neuropharmacology·Joanne A HarroldJason C G Halford
Jul 20, 2010·European Journal of Pharmacology·Azza Baraka, Samar ElGhotny
Jul 15, 2015·Peptides·J T DwarkasingK van Norren
Jan 5, 2011·Progress in Neuro-psychopharmacology & Biological Psychiatry·Annemarie HeberleinThomas Hillemacher
Mar 12, 2005·Obesity Research·José B C CarvalheiraMario J A Saad
Aug 20, 2016·Journal of Endocrinological Investigation·P FangP Bo
May 26, 2004·Physiology & Behavior·Gareth WilliamsJoanne A Harrold
May 8, 2007·The Journal of Physiological Sciences : JPS·Yong-Woon KimSo-Young Park
Jul 23, 2008·Developmental Disabilities Research Reviews·Jason C G Halford, Joanne A Harrold
Sep 1, 2006·Expert Review of Endocrinology & Metabolism·Miguel LópezCarlos Diéguez
Feb 21, 2008·American Journal of Physiology. Endocrinology and Metabolism·Jennifer W HillCarol F Elias
Feb 12, 2002·The Journal of Clinical Endocrinology and Metabolism·Anthony P GoldstoneDick F Swaab
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Jan 7, 2017·Journal of Molecular Endocrinology·Maggie C Evans, Greg M Anderson
May 22, 2016·BMC Neuroscience·J T DwarkasingK van Norren
Jun 23, 2021·Journal of Neuroendocrinology·Felipe Correa-da-SilvaChun-Xia Yi

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