Central lactogenic regulation of maternal behavior in rats: steroid dependence, hormone specificity, and behavioral potencies of rat prolactin and rat placental lactogen I

Endocrinology
R S BridgesP E Mann

Abstract

Adult virgin female rats display maternal behavior when continuously exposed to foster young for 5-6 days. Central infusions of PRL or placental lactogens (PLs) together with systemic treatment of progesterone (P) and estradiol (E2) stimulate maternal behavior in 1-2 days. In the present set of studies, it was asked whether the actions of lactogenic hormones are dependent upon both E2 and P and specific to lactogenic molecules. Moreover, we wanted to know whether central infusions of rat (r) PRL and PLs were equally effective in inducing maternal behavior. In the first study, adult virgin rats were ovariectomized (ovx) and stereotaxically fitted with bilateral cannulas directed at the medial preoptic area (MPOA). Rats were then assigned to one of four groups: P plus E2, blank (B) plus E2, P plus B, and B plus B. P-filled or B capsules were implanted sc on treatment day 1 and removed on day 11, whereas E2 or B capsules were implanted on day 11. All groups were infused with rPRL (40 ng/side) five times from days 11-13 and injected with bromocriptine (CB-154) sc (days 11-17) to suppress endogenous PRL release. Behavioral testing was conducted daily from days 12-17. It was found that exposure to both P and E2 was necessary to induc...Continue Reading

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Citations

Aug 13, 2004·Proceedings. Biological Sciences·James P CurleyEric B Keverne
Jun 13, 2002·Environmental Health Perspectives·Paola L PalanzaFrederick S vom Saal
Apr 7, 2010·Behavioural Brain Research·Fabiana Leopoldo de SousaMárcia Giovenardi
Oct 4, 2006·Frontiers in Neuroendocrinology·Christine K Wagner
Oct 23, 2001·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·M C BeinfeldL F Felicio
Nov 14, 2006·Behavioral and Cognitive Neuroscience Reviews·Michael Numan
Oct 28, 2005·Behavioral and Cognitive Neuroscience Reviews·Stephen C Gammie
Oct 5, 2010·Cell Transplantation·Benson Wui-Man LauKwok-Fai So
May 20, 1998·The Journal of Comparative Neurology·X J Pi, D R Grattan
Sep 30, 2000·Journal of Neuroendocrinology·G González-MariscalJ S Rosenblatt
Jul 27, 2001·Fundamental & Clinical Pharmacology·M AsadS Ramaswamy
Jul 8, 2008·Journal of Neuroendocrinology·D R Grattan, I C Kokay
Sep 2, 2005·Developmental Psychobiology·Jennifer K Gregg, Katherine E Wynne-Edwards
Feb 3, 2016·Journal of Neuroendocrinology·A B JanssenR M John
Aug 14, 1999·Journal of Neuroendocrinology·X J Pi, D R Grattan
Sep 4, 2018·Frontiers in Physiology·Tina NapsoAmanda N Sferruzzi-Perri
Jul 15, 2009·The Journal of Pain : Official Journal of the American Pain Society·L Vandy BlackMeredith T Robbins
Feb 23, 2011·Progress in Neuro-psychopharmacology & Biological Psychiatry·Kumi O KurodaMichael Numan

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