Central leptin increases insulin sensitivity in streptozotocin-induced diabetic rats

American Journal of Physiology. Endocrinology and Metabolism
Chia-Yu LinB Douglas White

Abstract

This study examined the effect of intracerebroventricular leptin on insulin sensitivity in streptozotocin (STZ)-induced diabetic rats. Male Wistar rats were cannulated in the lateral ventricle and, after recovery, administered either intravenous STZ (50 mg/kg) to induce diabetes or citrate buffer. Chronic leptin (10 microg/10 microl icv) or vehicle injections were administered daily for 14 days beginning 2 days after establishment of hyperglycemia in the diabetic animals. At the end of the 2 wk of injections, insulin sensitivity was measured by the steady-state plasma glucose (SSPG) method. Blood glucose concentrations were dramatically reduced and normalized by the 4th day in diabetic animals receiving intracerebroventricular leptin treatment. Diabetic animals exhibited insulin resistance, whereas intracerebroventricular leptin significantly enhanced insulin sensitivity, as indicated by decreased SSPG. Circulating leptin levels were not increased in animals injected with intracerebroventricular leptin. Thus the increased peripheral insulin sensitivity appears to be due solely to the presence of leptin in the brain, not to leptin acting peripherally. These data imply that inadequate central leptin signaling may lead to insulin ...Continue Reading

References

Jun 1, 1990·Diabetes Care·L RossettiR A DeFronzo
May 1, 1987·The Journal of Clinical Investigation·L RossettiR A DeFronzo
Sep 1, 1985·The American Journal of Physiology·E Dall'AglioG M Reaven
Dec 1, 1983·The American Journal of Clinical Nutrition·D W WrightG M Reaven
Oct 1, 1980·Metabolism: Clinical and Experimental·I ZavaroniG M Reaven
Jul 28, 1995·Science·M A PelleymounterF Collins
Jan 1, 1995·The American Journal of Physiology·A M StrackM F Dallman
May 1, 1994·European Journal of Clinical Investigation·S DrydenG Williams
Jan 22, 1996·FEBS Letters·J Rentsch, M Chiesi
Mar 27, 1996·Biochemical and Biophysical Research Communications·W I SivitzP Donohoue
Feb 15, 1996·Nature·G H LeeJ M Friedman
Jun 25, 1996·Proceedings of the National Academy of Sciences of the United States of America·N GhilardiR C Skoda
Sep 1, 1996·The Journal of Clinical Investigation·M W SchwartzD G Baskin
Oct 19, 1996·BMJ : British Medical Journal·T I SørensenJ C Holm
Aug 1, 1997·Endocrinology·W I SivitzW G Haynes
Dec 6, 1997·Nature·R J SeeleyM W Schwartz
Jan 31, 1998·The Journal of Clinical Investigation·N BarzilaiL Rossetti
Oct 31, 1998·Nature·J M Friedman, J L Halaas
May 26, 1999·Diabetes·D K SindelarM W Schwartz
Feb 26, 2000·Proceedings of the National Academy of Sciences of the United States of America·I Szanto, C R Kahn
Apr 6, 2000·American Journal of Physiology. Endocrinology and Metabolism·A SugaS Inoue

❮ Previous
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Citations

Apr 9, 2013·Indian Journal of Endocrinology and Metabolism·Thomas H Meek, Gregory J Morton
Aug 18, 2004·Proceedings of the National Academy of Sciences of the United States of America·Jin OshikawaYoshihiro Ishikawa
Sep 10, 2008·Proceedings of the National Academy of Sciences of the United States of America·Xinxin YuRoger H Unger
Sep 22, 2010·Proceedings of the National Academy of Sciences of the United States of America·Teppei FujikawaRoberto Coppari
Apr 30, 2011·Physiological Reviews·Gregory J Morton, Michael W Schwartz
Aug 30, 2011·Proceedings of the National Academy of Sciences of the United States of America·Bethany P CummingsPeter J Havel
Mar 12, 2013·Endocrine Reviews·Hyun-Seuk MoonChristos S Mantzoros
Oct 3, 2013·The Journal of Clinical Investigation·Gregory J MortonMichael W Schwartz
Jun 23, 2011·Reviews in Endocrine & Metabolic Disorders·Stephanie Sisley, Darleen Sandoval
Mar 1, 2003·Frontiers in Neuroendocrinology·Kevin D Niswender, Michael W Schwartz
Feb 9, 2013·Endocrinology and Metabolism Clinics of North America·Thomas SchererManfred Hallschmid
Apr 15, 2011·Trends in Endocrinology and Metabolism : TEM·Joseph S MarinoJennifer W Hill
Feb 16, 2011·Molecular and Cellular Endocrinology·Flavien BerthouMohammed Taouis
Jul 20, 2010·Physiology & Behavior·Ajaykumar N SharmaJames B Lucot
Feb 9, 2010·General and Comparative Endocrinology·Emma Burgos-RamosVicente Barrios
Mar 25, 2008·Neurobiology of Aging·Karen F HoldenUNKNOWN Health ABC study
Feb 6, 2008·Metabolism: Clinical and Experimental·Eric P PlaisanceRobert L Judd
Jun 3, 2008·Sleep Medicine Clinics·Jonathan Jun, Vsevolod Y Polotsky
Nov 4, 2015·The Journal of Clinical Investigation·Gregory J MortonMichael W Schwartz
Mar 13, 2016·Diabetologia·Thomas H Meek, Gregory J Morton
Mar 7, 2015·Life Sciences·Gabriela Fernández-FormosoSulay Tovar
Mar 28, 2012·Journal of Diabetes Investigation·Heather C DenrocheTimothy J Kieffer
Jul 30, 2015·Animal : an International Journal of Animal Bioscience·A FoskolosY R Boisclair
Mar 30, 2005·Behavioural Brain Research·Sandrine WetzlerChristiane Larue-Achagiotis
May 29, 2004·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·T G RamsayT A Davis
May 18, 2004·European Journal of Pharmacology·Yang ZhangDavid S Roane
May 21, 2013·Biochimica Et Biophysica Acta·Ruth B S Harris
Oct 18, 2012·Neurochemistry International·Arancha Perianes-CacheroVicente Barrios
Jun 5, 2012·Metabolism: Clinical and Experimental·Emma Burgos-RamosJohn J Kopchick
Jun 3, 2014·Critical Care : the Official Journal of the Critical Care Forum·Leigh A Callahan, Gerald S Supinski
May 10, 2013·Diabetes·Heather C DenrocheTimothy J Kieffer
May 31, 2016·Cell Metabolism·Maria ChondronikolaLabros S Sidossis
Jan 24, 2017·The Journal of Clinical Investigation·Rachel J PerryGerald I Shulman
Jan 24, 2017·The Journal of Clinical Investigation·Douglas Oberlin, Christoph Buettner
Jun 13, 2017·Diabetes·Jennifer D DeemMichael W Schwartz
Feb 19, 2004·American Journal of Physiology. Renal Physiology·Rui PedrosaP Soares-da-Silva
May 21, 2014·Nature Reviews. Neuroscience·Gregory J MortonMichael W Schwartz

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