Central memory CD4 T cells are the predominant cell subset resistant to anergy in SIV disease resistant sooty mangabeys

AIDS
Pavel BostikAftab A Ansari

Abstract

HIV infection in humans and experimental SIV infection in rhesus macaques leads to the loss of recall antigen responses, immunological anergy in CD4 T cells and AIDS. In contrast, natural infection in sooty mangabeys with SIV does not lead to disease despite high viral loads accompanied by resistance of their CD4 T cells to undergo immunological anergy. The objective of the study was to further elucidate the mechanisms that contribute to anergy resistance in CD4 T cells from sooty mangabeys and identify whether the anergy resistance is a function of a specific subset or the entire cell population. Susceptibility or resistance to anergy was analyzed in antigen specific and defined CD4 T cell subsets from peripheral blood of sooty mangabeys and rhesus macaques by using an in vitro anergy inducing protocol; expression of the anergy associated gene GRAIL was measured. Antigen specific CD4 T cells from SIV disease resistant sooty mangabey are relatively resistant to the development of anergy. This resistance is associated with a lack of an upregulation of GRAIL. Conversely, rhesus macaque CD4 T cells are sensitive to anergy induction associated with upregulation of GRAIL. Furthermore the anergy resistant phenotype of sooty mangabey ...Continue Reading

References

Jan 1, 1990·Annals of the New York Academy of Sciences·C L Ruegg, E G Engleman
Feb 28, 1998·Immunologic Research·C C Maier, M I Greene
Nov 6, 1998·Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association·G T BriceA A Ansari
Dec 21, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·P BostikA A Ansari
Dec 26, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·Christine J PitcherLouis J Picker
Sep 6, 2003·Frontiers in Bioscience : a Journal and Virtual Library·Pavel BostikAftab A Ansari
Dec 9, 2003·Nature Immunology·Luis SoaresC Garrison Fathman
Jan 7, 2004·Journal of Acquired Immune Deficiency Syndromes : JAIDS·J Bruce SundstromAftab A Ansari
Jan 7, 2004·Nature Reviews. Neuroscience·Raphael Lamprecht, Joseph LeDoux
Aug 6, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Barry T Rouse, Susmit Suvas

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Citations

Mar 4, 2008·Nature Medicine·Julien van GrevenyngheRafick-Pierre Sekaly
Mar 8, 2008·Expert Review of Vaccines·Rosemarie D MasonStephen J Kent
Oct 7, 2008·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Haiying LiHao Wu
Nov 17, 2010·The FEBS Journal·Chan C WhitingC Garrison Fathman
May 6, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jack T LinLinda Wu
Oct 29, 2019·PLoS Pathogens·Xavier Dagenais-LussierUNKNOWN Montreal Primary Infection Study Group

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