Central modulatory effects of tachykinin peptides on airway tone.

Journal of the Autonomic Nervous System
M A HaxhiuN S Cherniack

Abstract

Previous studies suggest that structures within 1 mm of the ventral surface of the medulla (VMS) are involved in the regulation of airway resistance. Furthermore, neurons containing tachykinin peptides have been observed near the surface of the VMS. In the present work, we examined the effects of mammalian tachykinins, substance P (SP) and neurokinin A (NKA), applied locally to the intermediate area of the VMS of cats on tracheal tone and phrenic nerve activity. Since neutral endopeptidase (enkephalinase) has been shown to degrade tachykinin peptides in other tissues, we also investigated the effect of the neutral endopeptidase (NEP) inhibitors (thiorphan and phosphoramidon) on airway tone and phrenic nerve responses to tachykinins when the animals were ventilated with 100% O2 and during hyperoxic hypercapnia and isocapnic hypoxia. Experiments were performed in chloralose-anesthetized cats hyperventilated to phrenic neural apnea or so that the end tidal CO2 was just above the apneic threshold. Trachealis smooth muscle tension was assessed by measuring changes in pressure in a balloon placed in a bypassed segment of trachea (Ptseg). Application to the VMS of SP (10(-5)-10(-3) M) significantly increased tracheal muscle tension. S...Continue Reading

References

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Citations

Dec 1, 1991·Respiration Physiology·M A HaxhiuN S Cherniack
Jun 1, 1992·Journal of the Autonomic Nervous System·T E DickN S Cherniack
Jan 1, 1995·Peptides·M D Yohannan, P Ernsberger
Sep 11, 2002·European Journal of Pharmacology·John C AnthesRobert W Egan
Jul 3, 2002·Respiratory Physiology & Neurobiology·Gina PeteEstelle B Gauda
Apr 18, 2002·Autonomic Neuroscience : Basic & Clinical·V John Massari, Musa A Haxhiu
Apr 3, 2010·Respiratory Physiology & Neurobiology·Prabha Kc, Richard J Martin
Nov 19, 2010·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·Brian P EnrightPatricia E Losco
Aug 19, 2008·Toxicology and Applied Pharmacology·Jianguo ZhuangMohan L Sopori
May 17, 2005·Journal of Applied Physiology·Musa A HaxhiuDonald G Ferguson
Oct 12, 1999·Journal of Applied Physiology·H GrasemannG T De Sanctis

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