Central motor conduction time by magnetic stimulation of the cortex and peripheral nerve conduction follow-up studies in Friedreich's ataxia

Electroencephalography and Clinical Neurophysiology
A Cruz-Martínez, F Palau

Abstract

A follow-up clinical study, peripheral motor and sensory nerve conduction velocities and central motor conduction by magnetic stimulation of the cortex were performed in 13 patients with classical Friedreich's ataxia (FA) phenotype, for a period of 9-12 years. Clinical worsening was unrelated to peripheral nerve abnormalities. The amplitude of the nerve action potentials and delayed conduction velocity remained unchanged for several years. Central motor conduction times were abnormal in all patients. Clinical conditions worsened significantly between successive examinations with significant increments in threshold and significant decrement of the amplitude of motor evoked potentials. The results are consistent with progressive pyramidal and cerebellar pathways involvement as the cause of clinical worsening in FA.

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Citations

Mar 17, 2004·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·Marjorie A Garvey, Donald L Gilbert
Apr 23, 2003·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Yi-Chung LeeBing-Wen Soong
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May 18, 2011·Developmental Medicine and Child Neurology·Deborah A SivalJohannes H Van Der Hoeven
Jan 12, 2021·Movement Disorders Clinical Practice·Gilles NaeijeXavier De Tiège

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