Central Nervous System Actinomycosis-A Clinicoradiologic and Histopathologic Analysis

World Neurosurgery
Niveditha RavindraJitender Saini

Abstract

Actinomycosis is an uncommon chronic suppurative infection that rarely affects the central nervous system (CNS). It is caused by filamentous Gram-positive anaerobic bacteria that is a normal commensal but causes suppurative and granulomatous inflammation after disruption of anatomical barriers. We report the largest series of 17 histologically confirmed cases of CNS actinomycosis and review clinical, imaging, and histopathologic features. All histologically confirmed cases of CNS actinomycosis diagnosed between January 2010 and June 2016 were retrieved from the neuropathology records. The demographic profile, clinical, radiologic, microbiologic, and histologic features, treatment, and clinical outcomes were reviewed. Seventeen cases were histopathologically diagnosed to have CNS actinomycosis. Nine of these were primarily admitted and managed in our institute, whereas the remaining 8 were referred to us for histopathologic diagnosis. Mean age at presentation was 31.4 years, with male predilection (3.25:1). Mean duration of symptoms was 2.95 months. Systemic symptoms were noted in 5 patients, although no systemic focus was detectable. Pachymeningitis was most common type (9; 52.94%), and chronic abscess was identified in 7. Hist...Continue Reading

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Citations

Jan 13, 2019·Primates; Journal of Primatology·Davi E R SousaMárcio B Castro
Jul 28, 2020·Frontiers in Neurology·Yanying WangLiying Cui
Nov 22, 2020·World Neurosurgery·Jiwook Ryu, Kyung Mi Lee
Nov 20, 2020·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Masayuki ShintakuYutaka Tsutsumi
Apr 28, 2021·Neurology India·Harshad S LimayePradyumna J Oak

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