PMID: 2497674Jan 1, 1989Paper

Central nervous system action of TRH to influence gastrointestinal function and ulceration

Annals of the New York Academy of Sciences
Y TachéT Ishikawa

Abstract

There is clear evidence in rats that TRH acts in the brain to stimulate gastric acid, pepsin, and serotonin secretion, mucosal blood flow, contractility, emptying, and ulceration through activation of parasympathetic outflow to the stomach (TABLE 3). A number of TRH analogues, including some devoid of TSH-releasing activity, mimic the effects of TRH. The most sensitive TRH sites of action to elicit gastric acid secretion and motility are located in the dorsal vagal complex and include the dorsal vagal, nucleus tractus solitarius, and nucleus ambiguus. The gastrointestinal tract is one of the most responsive visceral systems to the central effects of TRH, because doses in the range of 1-10 pmol in the dorsal vagal complex stimulate gastric function, whereas stimulation of cardiovascular and respiratory function on microinjection of the brainstem nuclei requires higher doses. Although fewer investigations have been carried out in other species, evidence from the available data clearly indicates that TRH acts in the brain to increase gastric secretion and motility in the rabbit, sheep, and cat. Lack of stimulation of gastric acid secretion after third ventricle injection in the dog may be related to species difference or to rapid ...Continue Reading

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Citations

Apr 1, 1993·Pharmacology, Biochemistry, and Behavior·K McMonagle-Strucko, R J Fanelli
May 1, 1997·Journal of Physiology, Paris·K A KovácsG Mózsik
Jan 1, 1995·Annual Review of Medicine·A Fullwood, D A Drossman
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Sep 25, 2002·The Journal of Biological Chemistry·Eduardo A NillniWilliam C Wetsel
Jan 31, 2002·World Journal of Gastroenterology : WJG·Masashi Yoneda
Jan 31, 2002·World Journal of Gastroenterology : WJG·Chuan-Yong LiuKe-Jing Liu
Oct 22, 2002·American Journal of Physiology. Gastrointestinal and Liver Physiology·Vicente MartínezYvette Taché
Jun 12, 2020·World Journal of Gastroenterology : WJG·Dong-Qin ZhaoHai-Ji Sun
Oct 4, 2014·American Journal of Physiology. Gastrointestinal and Liver Physiology·Luca Toti, R Alberto Travagli
Feb 8, 2003·Journal of Gastroenterology·Masashi YonedaAkira Terano

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