PMID: 589858Dec 1, 1977

Central nervous system arteriovenous malformations in multiple generations of a family with hereditary hemorrhagic telangiectasia

Clinical Genetics
C R KingJ Reiss

Abstract

Hereditary hemorrhagic telangiectasia is described in four generations of a kinship. The family is unique in that three generations manifest central nervous system vascular disease, which was pathologically confirmed in two generations. Genetic linkage was not identified for 32 genetic markers studied. The literature is reviewed for patients with central nervous system arteriovenous malformations and hereditary hemorrhagic telangiectasia. The pathogenesis of the disease is discussed, and therapeutic modalities are considered.

References

Feb 1, 1977·Archives of Neurology·H P AdamsE P Bosch
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Citations

Jul 7, 2001·Neurosurgery·S C Ohaegbulam
May 1, 1978·Clinical Genetics·A E Emery
Feb 1, 1994·Nature Genetics·C L ShovlinJ G Seidman
Dec 1, 1996·Journal of Neurosurgery·R LeblancR D Wilkinson
Apr 1, 1985·Journal of Neurosurgery·M C BoydD W Paty
Jun 1, 1992·Neurosurgery·A A de Sousa, F Dantas

Related Concepts

Intracranial Arteriovenous Malformation, Ruptured
Genealogical Tree
Hereditary Hemorrhagic Telangiectasia

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