Central nervous system atrophy and clinical status in multiple sclerosis

Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging
Robert Zivadinov, Rohit Bakshi

Abstract

In this review, the authors focus on clinical aspects of central nervous system (CNS) atrophy in multiple sclerosis (MS), including the relationship between atrophy and disability, disease course, disease duration, quality of life, and fatigue. Cross-sectional studies have demonstrated a moderate but significant correlation between brain or spinal cord atrophy and physical disability in patients with MS. Longitudinal studies (>/= 5 years) have shown that CNS atrophy is a significant predictor of subsequent long-term neurologic deterioration. The clinical relevance of CNS atrophy is reinforced by studies showing that atrophy accounts for more variance than conventional lesion measures in predicting disability. Impaired quality of life and both urodynamic and sexual dysfunction, but not fatigue, are associated with brain atrophy. It is likely that once the level of CNS atrophy reaches a critical threshold, patients begin to suffer clinical impairment and disease progression. Longitudinal studies suggest that CNS atrophy may occur in patients with clinically isolated demyelinating syndromes who are at high risk for developing clinically definite MS. Longitudinal natural history studies in relapsing-remitting, secondary progressive...Continue Reading

Citations

May 18, 2005·NeuroRx : the Journal of the American Society for Experimental NeuroTherapeutics·Rohit BakshiJerry S Wolinsky
Jun 17, 2008·AJNR. American Journal of Neuroradiology·Z LiptakC R G Guttmann
Dec 14, 2011·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Bing ChenXueguang Zhang
Jan 20, 2016·Neurodegenerative Disease Management·Eva Costa ArpínManuela Lema Bouzas
Dec 31, 2005·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Robert Zivadinov, Thomas P Leist
Dec 31, 2005·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Rohit Bakshi
Apr 18, 2012·Movement Disorders : Official Journal of the Movement Disorder Society·Johannes R StrefferRobert Alexander
Jul 18, 2015·Neurology. Neuroimmunology and Neuroinflammation·Francisco Carlos Pérez-MirallesXavier Montalban
Oct 12, 2010·Cell Cycle·Jin Young Kim, Patrizia Casaccia
Jun 27, 2009·Multiple Sclerosis : Clinical and Laboratory Research·D M MeadsB Eckert
Feb 27, 2013·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Darpan I Patel, Lesley J White
Jul 10, 2019·Neurological Research·Athina AndravizouEfthimios Dardiotis
Apr 8, 2020·Auto- Immunity Highlights·Athina AndravizouGeorgios M Hadjigeorgiou
Mar 15, 2015·Expert Review of Neurotherapeutics·Mark S Freedman, Mohammad Abdoli

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.