PMID: 9184653Jun 1, 1997Paper

Central nervous system cytokine mRNA expression following Theiler's murine encephalomyelitis virus infection

Journal of Neuroimmunology
S SatoR P Roos

Abstract

DA strain of Theiler's murine encephalomyelitis virus (TMEV) produces a biphasic disease with an initial self-limited acute gray matter polioencephalomyelitis in all strains of mice followed by, in the case of certain susceptible strains of mice, a chronic inflammatory demyelination of the spinal cord with a persistent virus infection. A pathogenic role for T-helper 1 (Th1) cells during the demyelinating phase of disease has been proposed. We characterized the cytokine mRNA expression in the brain and spinal cord of susceptible and resistant strains of mice during the early encephalomyelitic disease and the late demyelination, using a semi-quantitative reverse transcription-polymerase chain reaction (RT-PCR) assay. At the time of the encephalomyelitis, both resistant and susceptible mice expressed proinflammatory cytokine mRNAs followed by T-cell derived mRNAs; susceptible mice expressed more IL-12 p40 mRNA than resistant mice. During this early disease, there was no significant difference in Th1 cytokine mRNA expression in the brain and spinal cord among the four strains and relatively little Th2 type cytokine upregulation above levels seen in mock-infected controls. During the late demyelinating disease, susceptible but not r...Continue Reading

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Citations

Apr 15, 2010·Journal of Neural Transmission·Pascale Giraudon, Arlette Bernard
Jun 16, 2000·Journal of Neuroimmunology·F AloisiL Adorini
Jan 17, 2004·Clinical Microbiology Reviews·Emilia L OleszakChris D Platsoucas
Sep 13, 2005·Annual Review of Microbiology·Michel BrahicThomas Michiels
Aug 10, 2006·Journal of Neuropathology and Experimental Neurology·Reiner UlrichSusanne Alldinger
Jun 9, 2005·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Silvia Ortega-GutiérrezCarmen Guaza
Nov 22, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Herbert P M BrokBert A 't Hart
Jul 22, 2010·Microbiology and Immunology·Kazuo NakamichiMasayuki Saijo

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