Central nervous system effects of lactate infusion in primates

Biological Psychiatry
S R DagerD M Bowden

Abstract

The concentration of total lactate in cisternal fluid increased threefold, from 12.3 +/- 2.1 to 37.6 +/- 8.9 mg/dl, during a 20-min intravenous infusion of 1 M racemic sodium lactate (10 mEq/kg) in 3 anesthetized, mechanically ventilated baboons. Rises in cisternal lactate lagged behind arterial lactate increases, but occurred during the time interval in which susceptible humans typically panic in response to lactate infusion. Subsequent to cisternal lactate increases, cisternal pH and HCO3- concentration progressively increased during a 105-min interval following lactate infusion. No consistent changes in cisternal pCO2 occurred during or subsequent to lactate infusion. These preliminary findings fail to support the hypothesis that lactate-induced panic is mediated by increasing central nervous system pCO2. Instead, these data demonstrate that lactate can rapidly increase in the central nervous system during lactate infusion, suggesting new lines of investigation for studying the mechanisms responsible for lactate-induced panic.

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Citations

Nov 15, 1992·Biological Psychiatry·S R DagerG D Metzger
Jul 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·J PrichardR Shulman
Jan 26, 2010·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Stephen R Dager
May 23, 2009·Journal of Psychopharmacology·G EsquivelE J Griez

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