Central Nervous System Effects of Oral Propranolol for Infantile Hemangioma: A Systematic Review and Meta-Analysis

Journal of Clinical Medicine
Thuy ThaiJoshua D Brown

Abstract

Concerns about the effects of propranolol on the central nervous system (CNS) in the infantile hemangioma (IH) population have been raised. We conducted a meta-analysis of the CNS and sleep-related effects of oral propranolol in IH patients. PubMed, Embase, Cochrance, Web of Science, and Clinicaltrials.gov were searched for relevant studies. We included clinical trials that compared oral propranolol with other treatments among IH patients under 6 years old and monitored and reported any adverse events. Study characteristics, types and number of adverse events were abstracted. Cochrane Collaboration Risk of Bias Tool was used to assess risk of bias. Our main outcomes were CNS and sleep-related effects. Random-effects models were used to estimate the pooled risk ratio. We did not observe statistically significant associations between oral propranolol and CNS or sleep-related effects. Oral propranolol appeared to have a safer profile of CNS effects than corticosteroids (RR = 0.27, 95% CI 0.02⁻3.00), but had an increased risk versus non-corticosteroids (for CNS effect, RR = 1.40, 95% CI 0.86⁻2.27; for sleep-related effects, RR = 1.63, 95% CI 0.88⁻3.03). Despite no statistically significant associations, there were suggestive findin...Continue Reading

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Citations

Feb 6, 2020·World Journal of Pediatrics : WJP·Ellen M S XerfanJane Tomimori
Apr 20, 2021·Pediatric Dermatology·Elena Pope
Jun 19, 2021·European Journal of Pediatrics·Martin TheilerSalome Kurth
Jun 22, 2021·Pediatric Blood & Cancer·Jennifer L R MayerFrancine Blei
May 10, 2020·Current Pediatric Reviews·Alexander K C LeungKam L Hon

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Software Mentioned

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