PMID: 18406258Apr 15, 2008Paper

Central nervous system effects of leptin

Trends in Endocrinology and Metabolism : TEM
C BuchananD Brann

Abstract

Evidence exists demonstrating the importance of leptin in the control of energy homeostasis, feeding behavior and reproductive function. Leptin receptors are localized in several regions of the brain implicated in regulation of energy balance and reproductive function, including the arcuate nucleus/median eminence, paraventricular nucleus, and ventromedial nucleus. Administration of exogenous leptin has been shown to alter function of the hypothalamic-pituitary-adrenal axis and stimulate gonadotropin release through hypothalamic and pituitary actions. Results from in situ hybridization studies demonstrate the ability of leptin to modulate the expression of key neuropeptides (neuropeptide Y, corticotropin-releasing hormone) implicated in the regulation of energy homeostasis. This suggests that leptin is an important component in the neuroendocrine transmission line that regulates appetite, energy balance and reproduction.

References

Jan 1, 1990·Neuroscience and Biobehavioral Reviews·N J Rothwell
Jun 1, 1995·Current Opinion in Immunology·L M Karnitz, R T Abraham
Oct 1, 1995·The Journal of Clinical Investigation·D S WeigleJ L Kuijper
Oct 19, 1995·Nature·J N Ihle
Jul 28, 1995·Science·M A PelleymounterF Collins
Feb 15, 1996·Nature·G H LeeJ M Friedman
Jun 25, 1996·Proceedings of the National Academy of Sciences of the United States of America·N GhilardiR C Skoda
Jul 18, 1996·Nature·R S AhimaJ S Flier
Sep 1, 1996·The Journal of Clinical Investigation·M W SchwartzD G Baskin
Feb 1, 1997·The Journal of Clinical Investigation·R S AhimaJ S Flier
Feb 4, 1997·Proceedings of the National Academy of Sciences of the United States of America·W H YuS M McCann
Jun 24, 1997·Proceedings of the National Academy of Sciences of the United States of America·H FeiJ M Friedman
Oct 6, 1997·Neuroendocrinology·M E CouceR V Lloyd
Apr 1, 1963·The Journal of Physiology·G C KENNEDY, J MITRA

❮ Previous
Next ❯

Citations

Apr 15, 2008·Trends in Endocrinology and Metabolism : TEM·M J McKinley, B J Oldfield
Apr 24, 2012·Journal of Obesity·Fabio PanarielloVincenzo De Luca
Nov 23, 2007·European Journal of Pharmacology·Jayesh D Patel, Ivor S Ebenezer
Feb 11, 2009·Cell Biochemistry and Function·Yusuf Ziya ZiylanRasim Mogulkoc
Jun 30, 2010·Journal of Neuroendocrinology·B Del Bianco-BorgesC R Franci
Dec 13, 2006·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·E ErhardtH M T Barros
Jul 10, 2001·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·P C TsiotraS A Raptis
Oct 27, 2011·American Journal of Physiology. Endocrinology and Metabolism·Virendra B Mahesh
May 16, 2019·Journal of Leukocyte Biology·Lauar MonteiroPedro Manoel M Moraes-Vieira

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.