Central nervous system endoplasmic reticulum stress in a murine model of type 2 diabetes.

Diabetologia
C Sims-RobinsonEva L Feldman

Abstract

Type 2 diabetes is associated with complications in the central nervous system (CNS), including learning and memory, and an increased risk for neurodegenerative diseases. The mechanism underlying this association is not understood. The aim of this study was to gain greater insight into the possible mechanisms of diabetes-induced cognitive decline. We used microarray technology to identify and examine changes in gene expression in the hippocampus of a murine model of type 2 diabetes, the db/db mouse. Bioinformatics approaches were then used to investigate the biological significance of these genes. To validate the biological significance we evaluated mRNA and protein levels. At 8 and 24 weeks, 256 and 822 genes, respectively, were differentially expressed in the db/db mice. The most significantly enriched biological functions were related to mitochondria, heat shock proteins, or the endoplasmic reticulum (ER), the majority of which were downregulated. The ER-enriched cluster was one of the clusters that contained the highest number of differentially expressed genes. Several of the downregulated genes that were differentially expressed at 24 but not at 8 weeks are directly involved in the unfolded protein response (UPR) pathway a...Continue Reading

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Citations

Jul 12, 2013·PloS One·Catrina Sims-RobinsonEva L Feldman
Jan 3, 2014·Antioxidants & Redox Signaling·Phillipe D O'BrienEva L Feldman
Dec 23, 2014·Journal of Diabetes Research·Jacey Hongjie MaSarah X Zhang
Jun 3, 2014·International Journal of Molecular Sciences·Victoriano Pérez-VázquezSergio Encarnación-Guevara
Jan 18, 2016·Experimental Neurology·Catrina Sims-RobinsonEva L Feldman
Nov 13, 2012·Experimental Neurology·Sergey LupachykIrina G Obrosova
May 16, 2015·Molecular Neurobiology·Catrina Sims-RobinsonEva L Feldman
Jul 23, 2013·European Journal of Pharmacology·P Sytze Van DamNorman E Cameron
Feb 23, 2013·Diabetes·Norman E Cameron
Jul 12, 2017·Neural Plasticity·Jens Velde AndersenHelle Sønderby Waagepetersen

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