Central nervous system infections caused by varicella-zoster virus

Journal of Neurovirology
Francisco J ChamizoMaría José Pena

Abstract

We carried out a clinical and epidemiological study of adult patients with varicella-zoster virus central nervous system infection diagnosed by PCR in cerebrospinal fluid. Twenty-six patients were included. Twelve (46.2 %) patients were diagnosed with meningitis and fourteen (53.8 %) with meningoencephalitis. Twelve (46.2 %) had cranial nerves involvement (mainly the facial (VII) and vestibulocochlear (VIII) nerves), six (23.1 %) had cerebellar involvement, fourteen (53.8 %) had rash, and four (15.4 %) developed Ramsay Hunt syndrome. Three (11.5 %) patients had sequelae. Length of stay was significantly lower in patients diagnosed with meningitis and treatment with acyclovir was more frequent in patients diagnosed with meningoencephalitis. We believe routine detection of varicella-zoster virus, regardless of the presence of rash, is important because the patient may benefit from a different clinical management.

References

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Citations

Jan 25, 2017·Current Opinion in Infectious Diseases·Fiona McGillTom Solomon
Jun 14, 2017·Italian Journal of Pediatrics·Laura LancellaAlberto Villani
Nov 22, 2019·Indian Journal of Otolaryngology and Head and Neck Surgery : Official Publication of the Association of Otolaryngologists of India·Botros ShenodaWajahat Humayun
Dec 24, 2020·The American Journal of Emergency Medicine·Shadi Khalil, Eva Tovar Hirashima

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