Central nervous system infiltrates are characterized by features of ongoing B cell-related immune activity in MP4-induced experimental autoimmune encephalomyelitis

Clinical Immunology : the Official Journal of the Clinical Immunology Society
Helena BatoulisStefanie Kuerten

Abstract

In multiple sclerosis (MS) lymphoid follicle-like aggregates have been reported in the meninges of patients. Here we investigated the functional relevance of B cell infiltration into the central nervous system (CNS) in MP4-induced experimental autoimmune encephalomyelitis (EAE), a B cell-dependent mouse model of MS. In chronic EAE, B cell aggregates were characterized by the presence of CXCL13(+) and germinal center CD10(+) B cells. Germline transcripts were expressed in the CNS and particularly related to TH17-associated isotypes. We also observed B cells with restricted VH gene usage that differed from clones found in the spleen. Finally, we detected CNS-restricted spreading of the antigen-specific B cell response towards a myelin and a neuronal autoantigen. These data imply the development of autonomous B cell-mediated autoimmunity in the CNS in EAE - a concept that might also apply to MS itself.

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Citations

Jul 21, 2016·Scientific Reports·Damiano M RovitusoStefanie Kuerten
Mar 15, 2015·Trends in Molecular Medicine·Stefan Offermanns, Markus Schwaninger
Nov 9, 2016·Frontiers in Immunology·Meike Mitsdoerffer, Anneli Peters
Oct 30, 2016·Brain Pathology·Markus KippSandra Amor
Jan 31, 2020·Journal of Neuroinflammation·Nickoleta DelivanoglouConstantina Simeonidou
Jan 23, 2019·Histochemistry and Cell Biology·Luisa BellStefanie Kuerten
Nov 24, 2020·Frontiers in Neurology·Rittika ChunderStefanie Kuerten
Jan 4, 2017·Molecular Pharmaceutics·Laura NorthrupCory Berkland

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