Central nervous system involvement demonstrated by immunological study in prolymphocytic variant of chronic lymphocytic leukemia

Acta Haematologica
A López GuillermoC Rozman

Abstract

A patient with the prolymphocytic variant of B cell chronic lymphocytic leukemia (CLL/PL) who developed meningeal leukemic involvement is reported. He had been diagnosed as having CLL/PL 2.5 years earlier, and treated successively with splenectomy, continuous chlorambucil and CHOP chemotherapy. While receiving the latter treatment, the patient developed persistent cephalalgia and vomiting, without signs of neurological focality. A lumbar puncture yielded a cerebrospinal fluid (CSF) showing lymphoid cells of prolymphocytic appearance and the immunological cell markers demonstrated the clonality of these cells. Intrathecal methotrexate and arabinosyl cytosine treatment was administered, this leading to the disappearance of the abnormal cells from the CSF and the resolution of the clinical symptoms.

Citations

Oct 10, 1998·Cancer Practice·C MorrisonI W Flinn
Oct 7, 1995·Lancet·R PaoliniS Zamboni
Sep 21, 2013·Leukemia & Lymphoma·Maciek TatarczuchJohn F Seymour
Sep 14, 2007·Clinical Neurology and Neurosurgery·C P E LangeCh J Vecht
Nov 4, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Tsunayuki KakimotoAkaru Ishida
Sep 15, 2014·BMC Research Notes·Simone Lima de SouzaMaria Helena Ornellas

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