Central nervous system manifestations of a valproic acid overdose responsive to naloxone

Annals of Emergency Medicine
G AlbertoD Hryhorczuk

Abstract

We report the case of a 22-year-old man who presented with a depressed level of consciousness after ingesting valproic acid. He responded to IV naloxone; over a nine-hour period, his serum valproic acid level decreased from 180.4 to 59.2 micrograms/ml with multiple-dose charcoal therapy. We recommend the use of both agents in the treatment of valproic acid overdose.

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Citations

May 4, 2004·Annales Françaises D'anesthèsie Et De Rèanimation·V MinvilleK Samii
Feb 26, 1999·Annals of Emergency Medicine·F J Montero
Jan 26, 2002·The Journal of Emergency Medicine·Raymond J Roberge, Earlie H Francis
Jul 13, 2012·The New England Journal of Medicine·Edward W Boyer
Aug 31, 2001·Journal of Toxicology. Clinical Toxicology·G S WassermanS M Abdel-Rahman
Jul 29, 1999·Annals of Emergency Medicine·G F O'MalleyR C Dart
Dec 12, 2002·Journal of Toxicology. Clinical Toxicology·Matthew D Sztajnkrycer
Jan 1, 1995·Journal of Toxicology. Clinical Toxicology·G O Andersen, S Ritland
Jul 9, 2008·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Anthony S ManoguerraUNKNOWN American Association of Poison Control Centers
Jan 1, 2003·Expert Review of Neurotherapeutics·Benedikt Amann, Heinz Grunze
Dec 20, 2011·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Christie M Mock, Kristen H Schwetschenau
Oct 6, 2018·Clinical Medicine : Journal of the Royal College of Physicians of London·Lara Camilleri

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