PMID: 8586809Oct 1, 1995Paper

Central nervous system mediates an antihypertensive property in glucocorticoid hypertension in dogs

Journal of Hypertension
H NakamotoT Saruta

Abstract

To determine whether the central nervous system has a pressor or a depressor role in glucocorticoid-induced hypertension. Intracerebroventricular dexamethasone or its receptor antagonist, RU 38486, was administered in 20 trained conscious dogs. In addition, intracerebroventricular RU 38486 was administered in dogs treated with oral dexamethasone. Intracerebroventricular dexamethasone induced a dose-related reduction in blood pressure accompanied by decreased heart rate and cardiac output. In contrast, intracerebroventricular RU 38486 caused a slight but not significant elevation in blood pressure. Total peripheral resistance showed no significant change throughout the treatment with dexamethasone or RU 38486. In contrast, oral dexamethasone caused significant elevation of blood pressure associated with increased total peripheral resistance and reduced heart rate. In hypertensive dogs treated with oral dexamethasone, intracerebroventricular RU 38486 elicited a more severe form of hypertension accompanied by an attenuation of the heart rate and a reduction in cardiac output. Intracerebroventricular dexamethasone induced a significant reduction in plasma levels of adrenocorticotrophic hormone, cortisol, arginine vasopressin and no...Continue Reading

Citations

Aug 1, 2009·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Sharon Leng Hong OngJudith Ann Whitworth
Dec 20, 2008·Der Internist·C DodtF Sayk
Nov 14, 1997·Frontiers in Neuroendocrinology·E P Gómez-Sánchez

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