PMID: 8947946Nov 1, 1996Paper

Central nervous system myelin deficit in rats exposed to 2,4-dichlorophenoxyacetic acid throughout lactation

Neurotoxicology and Teratology
Ricardo DuffardA M Evangelista de Duffard

Abstract

Our results show that 2,4-dichlorophenoxyacetic acid (2,4-D) exposure through mother's milk during the period of rapid myelination (from the 15th to the 25th postnatal days) results in a myelin deficit in the pup's brain and demonstrates the vulnerability of the developing central nervous system (CNS) to 2,4-D. After 100 mg/kg 2,4-D administration to dams, brains of male and female rats show a significant diminution of myelin markers such as monohexosylceramide as well as phospholipids and free fatty acids (FFA) and an increase of cholesteryl esters. Histological studies revealed myelin deficit in some brain regions after 2,4-D treatment. These data indicate that 2,4-D, through the mother's milk, alters the myelination process during a specific postnatal period.

References

May 1, 1990·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·L C Schmued
Dec 1, 1987·Neurochemical Research·R O DuffardA M Evangelista de Duffard
Oct 1, 1973·Journal of Neurochemistry·W T Norton, S E Poduslo
Jan 1, 1962·Archives of Environmental Health·I DESIV MARKUS

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Citations

Apr 28, 2004·Neurotoxicity Research·C ThiffaultD A Di Monte
May 10, 2005·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Lalita BharadwajAdnan Ali
Sep 22, 2001·Chemico-biological Interactions·O Di PaoloR Duffard
Sep 16, 2003·Neurotoxicology and Teratology·Alejandro FerriAna María Evangelista de Duffard
Aug 10, 1999·Neurotoxicology and Teratology·A A BortolozziA M Evangelista de Duffard
Jun 20, 2013·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Carol J BurnsAbby A Li
May 8, 2008·Toxicological Sciences : an Official Journal of the Society of Toxicology·Cintia KonjuhRicardo Duffard
Sep 28, 2013·Toxicological Sciences : an Official Journal of the Society of Toxicology·Mary Sue MartyLarry Hammond
Oct 24, 2008·Environmental Health : a Global Access Science Source·Marina Bjørling-PoulsenPhilippe Grandjean
Jan 6, 2006·Environmental Health Perspectives·Theo Colborn
Apr 19, 2008·Toxicology·Nelson StürtzAna María Evangelista de Duffard
Mar 17, 2007·Drug and Chemical Toxicology·Alejandro FerriAna María Evangelista de Duffard
Jul 2, 2019·Human & Experimental Toxicology·L M FreitasF C Lima
Jul 10, 2002·Annals of the New York Academy of Sciences·Analía BortolozziAna María Evangelista de Duffard
Dec 23, 2020·Neurotoxicology·Vanessa NaffaaAnne-Laure Schang
Jun 19, 2004·Neurotoxicology and Teratology·Analía A BortolozziMarta C Antonelli
Oct 12, 2005·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·N StürtzR Duffard
Aug 13, 2011·Ecotoxicology and Environmental Safety·Afef TroudiNajiba Zeghal

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