Central nervous system pH in uremia and the effects of hemodialysis

The Journal of Clinical Investigation
A I ArieffV C Lazarowitz

Abstract

Rapid hemodialysis of uremic animals may induce a syndrome characterized by increased cerebrospinal fluid (CSF) pressure, grand mal seizures, and electroencephalographic abnormalities. There is a fall in pH and bicarbonate concentration in CSF, and brain osmolality exceeds that of plasma, resulting in a net movement of water into the brain. This syndrome has been called experimental dialysis disequilibrium syndrome. The fall in pH of CSF may be secondary to a fall of intracellular pH (pHi) in brain. Since changes in pHi can alter intracellular osmolality in other tissues, it was decided to investigate brain pHi in uremia, and the effects of hemodialysis. Brain pHi was measured by evaluating the distribution of 14C-labeled dimethadione in brain relative to CSF, while extracellular space was calculated as the 35504=/4 space relative to CSF. In animals with acute renal failure, brain (cerebral cortex) pHi was 7.06+/-0.02 (+/-SE) while that in CSF was 7.31+/-0.02, both values not different from normal. After rapid hemodialysis (100 min) of uremic animals, plasma creatinine fell from 11.8 to 5.9 mg/dl. Brain pHi was 6.89+/-0.02 and CSF pH and 7.19+/-0.02, both values significantly lower than in uremic animals (P less than 0.01), and...Continue Reading

References

Sep 21, 1967·The New England Journal of Medicine·J B Posner, F Plum
Aug 21, 1972·JAMA : the Journal of the American Medical Association·C M GrushkinR N Fine
Feb 11, 1971·The New England Journal of Medicine·J L OhmanG P Kozak
Dec 1, 1969·Annals of Internal Medicine·B J RosenbaumS G Massry
Jun 1, 1966·Acta Physiologica Scandinavica·U Pontén, B K Siesjö
Feb 1, 1974·The Journal of Clinical Investigation·A I Arieff, S G Massry
Feb 23, 1963·Lancet·A C KENNEDYS RENFREW
Mar 1, 1964·The Journal of Clinical Investigation·R F KIBLERE D ROBIN

Citations

Nov 1, 1995·Journal of Neuroscience Research·M I ChuahI Jacobs
Jun 20, 2012·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Diana Zepeda-Orozco, Raymond Quigley
Mar 10, 2009·Neurocritical Care·Jeffrey J FletcherPaul A Blostein
Mar 1, 1978·JACEP·C J McAllister, R Gibson
Mar 20, 1986·The New England Journal of Medicine·S W Brusilow, R Traystman
Jun 20, 2012·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Giuseppe RegolistiEnrico Fiaccadori
Jun 12, 2010·The Journal of Trauma·Jeffrey J FletcherPaul A Blostein
Sep 4, 2008·Seminars in Dialysis·Nilang PatelMandip Panesar
May 12, 2009·Seminars in Dialysis·A Davenport
Nov 1, 1979·The Journal of Small Animal Practice·A R Michell
Dec 17, 1998·Journal of Neurology, Neurosurgery, and Psychiatry·D J Burn, D Bates
Jul 3, 2004·Nephron. Clinical Practice·Mahendra AgraharkarTejinder S Ahuja
Jan 1, 1983·Intensive Care Medicine·Y M BertrandJ Roels
Mar 24, 2015·The American Journal of the Medical Sciences·Faraz Khan LuniSandeep Vetteth
Nov 1, 1982·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·C A Mahoney, A I Arieff
Sep 1, 1978·Kidney International·A I ArieffR Guisado
Dec 1, 1989·Kidney International·C R Kleeman
Aug 1, 1983·Kidney International·C A Mahoney, A I Arieff
Dec 1, 1980·Kidney International
Mar 3, 2001·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·A Davenport
Jul 11, 1992·Kidney International·S M SilverR H Sterns
Jul 22, 2008·Hemodialysis International·Ravindra Prabhu AtturWaqas Wahid Baig
Jul 22, 2008·Hemodialysis International·Ernesto Lopez-Almaraz, Ricardo Correa-Rotter
Sep 10, 2016·Seminars in Dialysis·Jochen G RaimannTodd S Ing
Dec 1, 1986·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·A M Hakim, M Arrieta
Dec 13, 2018·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·J R LugonA J Peixoto
Feb 1, 2008·NDT Plus·A Davenport
Oct 1, 2013·Clinical Kidney Journal·Shamir TuchmanKirtida Mistry
Jan 1, 2001·Hemodialysis International·Mandeep M SahaniTodd S Ing

Related Concepts

Acid-Base Imbalance
Brain
Cerebrospinal Fluid
Canis familiaris
Hemodialysis
Hydrogen-Ion Concentration
Osmolality
Uremia

Related Feeds

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.