PMID: 3753657Mar 1, 1986Paper

Central nervous system prophylaxis with combined intravenous and intrathecal methotrexate in diffuse lymphoma of aggressive histologic type

Cancer
R Perez-SolerF Cabanillas

Abstract

With the use of a multivariate regression model, 21 patients with diffuse lymphoma were identified as having greater than 15% risk of experiencing relapse in the central nervous system (CNS). The efficacy of a combination of sequential intravenous methotrexate (MTX) (1 g/m2) and intrathecal MTX in preventing relapse in the CNS and improving survival times was assessed. A comparable historical control group of patients with similar risk of CNS relapse and who did not receive any CNS prophylaxis was used. The CNS relapse-free survival rate (RFS) was improved in patients who received CNS prophylaxis (95% versus 59% at 2 years; P = 0.01). Pretreatment serum lactic dehydrogenase (LDH) levels correlated with the incidence of relapse in the CNS in the control group (P = 0.01). In patients with high pretreatment serum LDH levels (greater than 225 U/L), CNS RFS was improved in those who received CNS prophylaxis (RFS at 2 years: 91% versus 46%; P = 0.02). Both CNS RFS (100% versus 38% at 2 years; P = 0.03) and survival rates (100% versus 38% at 2 years; P = 0.02) were improved in six patients with histologic type other than large cell. In 15 patients with large cell lymphoma, no significant differences in CNS RFS (93% versus 75% at 2 yea...Continue Reading

References

Mar 1, 1983·The American Journal of Medicine·F CabanillasE J Freireich
Feb 1, 1983·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A T SkarinE Frei
Dec 1, 1983·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·L S FrankelJ Pullen
Sep 1, 1983·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·H J WeinsteinR Levey
Jan 1, 1981·Cancer·D J StewartE J Freireich
Mar 1, 1959·Journal of Neurosurgery·W E HUNTJ N MEAGHER
Feb 1, 1961·Medicine·S A ROSENBERGL F CRAVER

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Citations

Feb 19, 2002·International Journal of Radiation Oncology, Biology, Physics·Abderrahim ZouhairUNKNOWN Rare Cancer Network
May 31, 2002·Internal Medicine Journal·Jeremy Wellwood, K Taylor
Aug 15, 2002·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A HollenderH Holte
Dec 25, 2008·Current Opinion in Oncology·Hwee Yong LimMichael J Glantz
Aug 24, 2006·International Journal of Hematology·Naoto TomitaYoshiaki Ishigatsubo
Aug 11, 2010·Critical Reviews in Oncology/hematology·Fabio CanovaSavina Maria Luciana Aversa
Jun 1, 1990·Journal of the American Academy of Dermatology·P L MyskowskiB Safai
Oct 4, 2005·British Journal of Haematology·C W CheungK M Ardeshna
Sep 17, 2013·British Journal of Haematology·Andrew McMillanUNKNOWN British Committee for Standards in Haematology
Jul 1, 1988·Current Problems in Cancer·W A Bleyer, T N Byrne
Aug 4, 2006·Blood Reviews·Quentin A Hill, Roger G Owen
Aug 9, 2005·Hematology/oncology Clinics of North America·Silvia Montoto, T Andrew Lister
Apr 15, 2003·Neurologic Clinics·Lawrence Recht, Maciej Mrugala
Apr 21, 2016·European Journal of Haematology·Mohammad Faizan ZahidStefan K Barta
Nov 26, 2002·Hematology·Andrew ListerJohn T Sandlund
Nov 3, 2016·Clinical Nuclear Medicine·Molly P HoganGary A Ulaner
Sep 1, 1990·Arquivos de neuro-psiquiatria·J D CorrealeN Lucatelli
Mar 3, 2007·Journal of Neuro-oncology·B Gleissner, M Chamberlain

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