PMID: 7014330Mar 1, 1981Paper

Central nervous system regulation of liver and adipose tissue metabolism

Diabetologia
T Shimazu

Abstract

Hypothalamic and autonomic nervous regulation of carbohydrate and amino acid metabolism in the liver and of lipid metabolism in adipose tissues is described. The direct neural mechanism underlying this regulation has been evaluated. Electrical stimulation of the ventromedial hypothalamic nucleus (VMH)-splanchnic nerve system causes glycogenolysis in the liver by rapid activation of glycogen phosphorylase, whereas electrical stimulation of the lateral hypothalamic nucleus (LH)-vagus nerve system promotes glycogenesis in the liver by activation of glycogen synthetase, through direct neural and neural-hormonal mechanisms. Studies on chemical coding of the hypothalamic neurones have revealed that norepinephrine-sensitive neurones in the VMH and acetylcholine-sensitive neurones in the LH are specifically involved in the regulation of liver phosphorylase and glycogen synthetase, respectively. Acetylcholine-sensitive neurones of the LH were also found to be concerned in regulation of hepatic tyrosine and aminotransferase activity, through intermediation of the cholinergic system in the LH-vagal pathway. Finally, it has been shown that the VMH acts as a regulatory centre for lipolysis in adipose tissues by modulating activation of the ...Continue Reading

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Citations

Sep 1, 1987·Pflügers Archiv : European journal of physiology·M IwaiT Shimazu
Oct 2, 1995·Brain Research·Y HashiguchiN N Abumrad
Aug 1, 1984·Physiology & Behavior·S KuchárK Boda
Oct 1, 1984·Physiology & Behavior·L L BellingerT W Castonguay
Jan 1, 1986·Physiology & Behavior·D K ThomasK Gillette
Dec 1, 1990·Physiology & Behavior·A J Scheurink, A B Steffens
May 1, 1992·Physiology & Behavior·Z J YangM M Meguid
Jan 1, 1987·Advances in Enzyme Regulation·K JungermannH Hartmann
Apr 1, 1985·Pharmacology, Biochemistry, and Behavior·L L BernardisE Lebenthal
Nov 1, 1990·Pharmacology, Biochemistry, and Behavior·C M CuriM S Dolnikoff
Jan 1, 1996·Neuroscience and Biobehavioral Reviews·E I OparaW G Hammond
Jan 1, 1982·Progress in Lipid Research·J G McCormack
Sep 1, 1982·Journal of the Autonomic Nervous System·A Takahashi, T Shimazu
Feb 1, 1983·Journal of the Autonomic Nervous System·R C Rogers, G E Hermann
Jun 1, 1983·Journal of the Autonomic Nervous System·M S DolnikoffN S Hell
Mar 1, 1984·Journal of the Autonomic Nervous System·P G LuitenA B Steffens
Oct 1, 1987·Journal of the Autonomic Nervous System·N M AppelG R Van Loon

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