Central nervous system trauma and stroke. I. Biochemical considerations for oxygen radical formation and lipid peroxidation

Free Radical Biology & Medicine
J M Braughler, E D Hall


The generation of oxygen radicals and the process of lipid peroxidation have become a focus of attention for investigators in the fields of central nervous system (CNS) trauma and stroke (e.g., ischemia). Considering our level of understanding of free radical and lipid peroxidation chemistry, absolute proof for their involvement in the pathophysiology of traumatic and ischemic damage to the CNS has been meager. While direct, unequivocal evidence for the participation of free radicals and lipid peroxidation as primary contributors to the death of neuronal tissue waits to be established, numerous recent studies have provided considerable support for the occurrence of free radical and lipid peroxidation reactions in the injured or ischemic CNS. In addition, the pharmacological use of antioxidants and free radical scavengers in the treatment of experimental CNS trauma and ischemia has provided convincing, although indirect evidence, for the involvement of oxygen radicals and lipid peroxidation in these conditions. The intent of this and its companion paper is to review: 1) the biochemical processes which may give rise to free radical reactions in the CNS, 2) the environment of the ischemic cell as it may affect the generation of ox...Continue Reading


Jan 13, 2006·BioFactors·Kamelija ZarkovicNeven Zarkovic
May 7, 2002·Journal of Neuroscience Research·Rinat TabakmanRon Kohen
Nov 22, 2001·Experimental Neurology·M C LeeS U Kim
Jan 1, 1995·Biological Trace Element Research·R VagnozziB Giardina
May 1, 1997·Molecular and Chemical Neuropathology·R L RoofD G Stein
Jun 27, 1998·Molecular and Chemical Neuropathology·L HorákováL Derková
Jun 1, 1995·Molecular and Chemical Neuropathology·J BurdaJ Marsala
Feb 1, 1991·Molecular and Chemical Neuropathology·Y J YangP L Yu
Oct 26, 2005·The Journal of Membrane Biology·G Stark
Sep 12, 2008·Biological Trace Element Research·Dervis Ozcelik, Hafize Uzun
Oct 5, 2007·Molecular Biotechnology·Devendra K Rai, Bechan Sharma
Dec 31, 2011·Translational Stroke Research·Adam R FergusonJessica L Nielson
Jan 1, 1995·The Annals of Thoracic Surgery·M C MauneyC G Tribble
Sep 5, 1995·European Journal of Pharmacology·N EshharA Biegon
Aug 1, 1992·Journal of the Neurological Sciences·D LombardiR Rodriguez y Baena
Jun 1, 1995·Journal of the Neurological Sciences·D L SamudralwarW R Markesbery
Dec 1, 1995·Journal of the Neurological Sciences·E D Hall
Jan 1, 1994·Pharmacology & Therapeutics·M E GötzM B Youdim


Feb 14, 1979·Biochemical and Biophysical Research Communications·R J Gaudet, L Levine
Jan 1, 1986·Free Radical Research Communications·J M Gutteridge
Jan 17, 1985·The New England Journal of Medicine·J M McCord
Mar 1, 1985·Archives of Biochemistry and Biophysics·J F TurrensA L Lehninger
Apr 7, 1986·FEBS Letters·J F Koster, R G Slee
May 1, 1986·Journal of Neurosurgery·H A Kontos, E P Wei
Jan 1, 1985·Journal of Free Radicals in Biology & Medicine·S D AustC E Thomas
Feb 1, 1987·The Journal of Clinical Investigation·S M SadrzadehJ W Eaton
Dec 1, 1986·Circulation Research·R C KukrejaE F Ellis
Mar 9, 1987·FEBS Letters·P C MoorhouseJ M Gutteridge
Feb 1, 1986·Journal of Neurochemistry·R von HanwehrB K Siesjö
Oct 17, 1987·Biochimica Et Biophysica Acta·J M BraughlerJ F Pregenzer
Nov 1, 1988·Archives of Biochemistry and Biophysics·M A Babizhayev
Feb 1, 1988·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·J J GromeD I Graham
May 1, 1986·Biochemical Pharmacology·S ChakrabartiR Shankar
Jan 1, 1985·Journal of Free Radicals in Biology & Medicine·N R NayiniJ Komara
Jan 1, 1985·Journal of Free Radicals in Biology & Medicine·A Sevanian, E Kim
Feb 1, 1985·Journal of Molecular and Cellular Cardiology·D E ChambersJ M Downey
Jan 1, 1985·British Journal of Anaesthesia·J D Miller
Jan 1, 1985·Journal of Free Radicals in Biology & Medicine·W E Lands
Mar 1, 1986·Stroke; a Journal of Cerebral Circulation·J M HallenbeckT J Contreras
Apr 1, 1985·The Journal of Experimental Medicine·S S PanterJ W Eaton
May 1, 1985·Journal of Neurochemistry·S YoshidaM D Ginsberg
Mar 1, 1985·Neurochemical Research·M M Zaleska, R A Floyd
Jun 28, 1973·Clinica Chimica Acta; International Journal of Clinical Chemistry·J W HartzH F Deutsch
Aug 1, 1974·Journal of Neurochemistry·P KleihuesK A Hossmann
May 1, 1981·Journal of Neurochemistry·J FolbergrováB K Siesjö
Jan 1, 1981·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·B K Siesjö
May 1, 1984·Journal of Neurosurgery·B K Siesjö
Sep 1, 1984·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·V R Marcy, F A Welsh

Related Concepts

Central Nervous System
Cerebrovascular Occlusion
Free Radicals
Trauma, Nervous System
Saturated Fat
Lipid Peroxidation

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