Central Nervous System Underpinnings of Sensory Hypersensitivity in Migraine: Insights from Neuroimaging and Electrophysiological Studies

Headache
Geneviève Demarquay, François Mauguière

Abstract

Whereas considerable data have been generated about the pathophysiology of pain processing during migraine attacks, relatively little is known about the neural basis of sensory hypersensitivity. In migraine, the term "hypersensitivity" encompasses different and probably distinct pathophysiological aspects of sensory sensitivity. During attacks, many patients have enhanced sensitivity to visual, auditory and/or olfactory stimuli, which can enhance headache while interictally, migraineurs often report abnormal sensitivity to environmental stimuli that can cause nonpainful discomfort. In addition, sensorial stimuli can influence and trigger the onset of migraine attacks. The pathophysiological mechanisms and the origin of such sensitivity (individual predisposition to develop migraine disease or consequence of repeated migraine attacks) are ill understood. Functional neuroimaging and electrophysiological studies allow for noninvasive measures of neuronal responses to external stimuli and have contributed to our understanding of mechanisms underlying sensory hypersensitivity in migraine. The purpose of this review is to present pivotal neuroimaging and neurophysiological studies that explored the basal state of brain responsiveness...Continue Reading

References

Dec 1, 1991·Cephalalgia : an International Journal of Headache·J Bánk
Apr 1, 1989·Headache·M E DrakeH Padamadan
Jan 1, 1986·Annals of Neurology·A Maertens de NoordhoutJ Schoenen
Dec 1, 1968·Electroencephalography and Clinical Neurophysiology·W RitterL D Costa
Jan 1, 1995·Neurophysiologie clinique = Clinical neurophysiology·W WangM Timsit-Berthier
Oct 1, 1993·Cephalalgia : an International Journal of Headache·P D Drummond, A Woodhouse
Feb 1, 1993·Cephalalgia : an International Journal of Headache·P Kropp, W D Gerber
Nov 20, 1997·Brain : a Journal of Neurology·P D Drummond
Dec 17, 1997·Cephalalgia : an International Journal of Headache·J VanagaiteL J Stovner
Apr 29, 1998·Brain : a Journal of Neurology·J AfraJ Schoenen
Jul 23, 1998·Cephalalgia : an International Journal of Headache·W Wang, J Schoenen
Feb 6, 1999·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·T W BuddP T Michie
Jun 4, 1999·Brain : a Journal of Neurology·R OelkersJ Lötsch
Jul 14, 1999·Cephalalgia : an International Journal of Headache·S EversI W Husstedt
Nov 26, 1999·Cephalalgia : an International Journal of Headache·W WangY H Wang
May 29, 2000·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·J AfraJ Schoenen
Dec 29, 2000·Cephalalgia : an International Journal of Headache·K GrosserJ Lötsch
Mar 10, 2001·Journal of the Neurological Sciences·M YilmazS Pençe
May 3, 2002·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Y Ozkul, A Uckardes
Jun 14, 2003·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Jean SchoenenAlain Maertens de Noordhout
Aug 16, 2003·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Marina de TommasoFranco Michele Puca
Sep 3, 2003·Cephalalgia : an International Journal of Headache·M SiniatchkinW-D Gerber
Jul 21, 2004·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Kenji SakumaKenji Nakashima
Jul 22, 2004·Cephalalgia : an International Journal of Headache·M de TommasoF M Puca
Sep 15, 2004·Neurology·Ninan T MathewTad Seifert
Oct 9, 2004·Brain : a Journal of Neurology·Eberhard LangSia Seidler
Mar 19, 2005·Cephalalgia : an International Journal of Headache·R Oelkers-AxM Weisbrod
Jun 28, 2005·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Marina de TommasoPaolo Livrea
Jul 27, 2005·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·K ShibataS Ohkawa
Mar 3, 2006·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·John Polich, José R Criado

❮ Previous
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Citations

Apr 23, 2013·Revue neurologique·M Denuelle, N Fabre
Sep 3, 2017·Applied Psychophysiology and Biofeedback·Jeffrey J SableFrank Andrasik
Dec 6, 2016·Cephalalgia : an International Journal of Headache·Martin UglemTrond Sand
Oct 20, 2018·Pain·Hadas Nahman-AverbuchRobert C Coghill
Feb 10, 2019·Headache·Daniel P Hayne, Paul R Martin
Jan 10, 2019·Pain·Hadas Nahman-AverbuchRobert C Coghill
Mar 20, 2018·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Nazia KarsanGregory Dussor
Mar 17, 2018·AJNR. American Journal of Neuroradiology·J D SantoroK W Yeom
Oct 4, 2018·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Tülin AktürkLevent Ertuğrul İnan
Dec 4, 2019·Cephalalgia : an International Journal of Headache·Hanna Sophie LappGudrun Gossrau
Aug 6, 2019·Frontiers in Integrative Neuroscience·Tami Bar-ShalitaIrit Weissman-Fogel
Jul 19, 2018·The Journal of Headache and Pain·Ching-I HungShuu-Jiun Wang
May 6, 2019·The Journal of Headache and Pain·Antonio RussoGioacchino Tedeschi
Dec 7, 2018·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Jong-Geun Seo, Sung-Pa Park
Nov 12, 2020·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Melissa M CortezK C Brennan
Jul 4, 2020·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Rémy MassonAnne Caclin

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